TMS measures in controls and patient groups
| TMS variable | Control | sALS | homD90A | |||
|---|---|---|---|---|---|---|
| Values are mean (SD). Areas R and A are % CMAP; area ISI values are % unconditioned. *Significant group differences from controls (p<0.05). A, muscle in activated state; CMAP, compound motor action potential; CMCT, central motor conduction time; homD90A, homozygous D90A SOD1 ALS; ISI, interstimulus interval; R, muscle in relaxed state; sALS, sporadic amyotrophic lateral sclerosis; SP, silent period; t, threshold; TMS, transcranial magnetic stimulation. | ||||||
| Threshold | 53 (8) | 63 (17)* | 65 (18)* | |||
| CMCT | 7 (1) | 8 (1)* | 9 (2)* | |||
| Area R 0.9 t | 0 (1) | 0 (1) | 0 (0) | |||
| Area R 1.0 t | 1 (2) | 1 (1) | 1 (1) | |||
| Area R 1.1 t | 4 (4) | 5 (6) | 2 (2) | |||
| Area R 1.2 t | 9 (10) | 10 (10) | 7 (8) | |||
| Area R 1.3 t | 18 (16) | 18 (19) | 12 (14) | |||
| Area A 0.9 t | 4 (5) | 8 (10) | 6 (11) | |||
| Area A 1.0 t | 9 (10) | 12 (15) | 13 (12) | |||
| Area A 1.1 t | 29 (25) | 24 (22) | 15 (12) | |||
| Area A 1.2 t | 42 (22) | 41 (36) | 23 (16) | |||
| Area A 1.3 t | 57 (24) | 42 (39) | 30 (19)* | |||
| SP duration 0.9 t | 72 (24) | 94 (45) | 86 (39) | |||
| SP duration 1.0 t | 99 (27) | 113 (44) | 120 (50) | |||
| SP duration 1.1 t | 136 (33) | 140 (48) | 131 (56) | |||
| SP duration 1.2 t | 156 (27) | 160 (53) | 151 (67) | |||
| SP duration 1.3 t | 169 (32) | 177 (57) | 155 (67) | |||
| Area ISI 1 ms | 22 (21) | 49 (44)* | 31 (33) | |||
| Area ISI 2 ms | 23 (26) | 51 (58)* | 15 (16) | |||
| Area ISI 3 ms | 39 (56) | 71 (104) | 31 (29) | |||
| Area ISI 4 ms | 48 (45) | 105 (238) | 18 (18) | |||
| Area ISI 5 ms | 84 (65) | 92 (131) | 38 (39) | |||
| Area ISI 7 ms | 155 (130) | 123 (90) | 97 (45) | |||
| Area ISI 10 ms | 239 (206) | 136 (80)* | 144 (123) | |||
| Area ISI 20 ms | 161 (202) | 126 (83) | 171 (184) | |||
| Area ISI 50 ms | 141 (94) | 66 (66)* | 116 (63) | |||