Effect of the −219 G/T polymorphism on amyloid load according to age in the brains of 114 patients with Alzheimer’s disease
| Genotype | Age less than median* | Age more than median* | p Value | |||
|---|---|---|---|---|---|---|
| GG+GT | TT | p Value | GG+GT | TT | ||
| Values are mean per cent amyloid load with (range). | ||||||
| *Age classes were defined by median age at death (72.5 years). | ||||||
| n | 42 | 16 | 36 | 20 | ||
| Plaque Aβn-40 | 2.0 (0.3 to 12.3) | 3.0 (1.1 to 8.35) | NS | 0.9 (0.2 to 5.5) | 3.2 (1.2 to 8.9) | 0.007 |
| Plaque Aβn-42 | 9.3 (5.8 to 15.0) | 9.7 (6.1 to 15.4) | NS | 8.4 (5.2 to 13.6) | 11.0 (6.9 to 17.5) | 0.035 |
| Total plaque Aβ | 12.4 (7.5 to 20.6) | 13.5 (8.1 to 22.5) | NS | 10.5 (6.4 to 17.4) | 15.2 (9.1 to 25.2) | 0.016 |