Histopathological study of the sural nerve
| HNPP (n = 14) | Controls (n = 13) | |||||||
|---|---|---|---|---|---|---|---|---|
| Mean (SD) | p Values for controls* | Correlation to aging | Mean (SD) | Correlation to aging | ||||
| r † | Regression slope | p Values for controls‡ | r † | Regression slope | ||||
| *Mann-Whitney U test; †Pearson’s correlation coefficient; ‡regression slopes of HNPP and controls were compared. | ||||||||
| NS, not significant. | ||||||||
| Myelinated fibre density (no./mm2) | ||||||||
| Total | 7738 (1253) | NS | −0.45 | −29.6 | NS | 8561 (1289) | −0.73 | −39.9 |
| Large | 2458 (730) | <0.01 | −0.70 | −27.1 | NS | 3258 (736) | −0.83 | −26.0 |
| Small | 5280 (1025) | NS | −0.05 | −2.5 | NS | 5302 (655) | −0.50 | −13.9 |
| Teased fibre study (%) | ||||||||
| Tomacular change | 41.5 (15.8) | – | −0.21 | −0.18 | – | – | – | – |
| Segmental de/re-myelination | 25.6 (13.9) | <0.001 | 0.39 | 0.30 | NS | 6.9 (6.5) | 0.82 | 0.22 |
| Axonal degeneration | 3.6 (3.8) | NS | −0.35 | −0.07 | <0.05 | 1.6 (1.8) | 0.81 | 0.06 |