Table 1

 Brain areas of significant activation during the sex discrimination, semantic decision and finger-tapping tasks in normal volunteers and the patient with pathological laughing before and after treatment

Normal groupThe patient with pathological laughing
Without paroxetineWith paroxetine
MCP, middle cerebellar peduncle; Rt., right; Lt, left.
(A) The sex discrimination task (12 normal volunteers and the patient)
Rt. Fusiform gyrusPonsLt. fusiform gyrus
(40, −78, −16)(6, −36, −22)(−38, −42, −28)
(Z = 5.55)(Z = 5.27)(Z = 7.46)
Lt. Fusiform gyrusLt. fusiform gyrusLt. inferior temporal gyrus
(−38, −76, −16)(−38, −42, −28)(−40, −66, −2)
(Z = 4.85)(Z = 8.00)(Z = 4.38)
Rt. amygdalaLt. amygdala
(16, −6, −18)(−22, −10, −14)
(Z = 4.33)(Z = 5.78)
Lt. amygdalaLt. inferior temporal gyrus
(−16, −6, −18)(−40, −68, 2)
(Z = 4.47)(Z = 5.15)
Rt. inferiot frontal gyrusRt. cerebellum (MCP)
(46, 14, 26)(12, −40, −30)
(Z = 5.57)(Z = 4.63)
Lt. middle frontal gyrusLt. cerebellum (MCP)
(−36, 8, 34)(−8, −42, −38)
(Z = 4.20)(Z = 4.40)
Rt. hippocampus
(34, −16, −16)
(Z = 4.05)
Rt. lingual gyrus
(22, −70, 2)
(Z = 4.17)
(B) The semantic decision task (11 normal volunteers and the patient)
Rt. lingual gyrusPonsRt. lingual gyrus
(32, −80, −20)(2, −34, −32)(22, −72, −18)
(Z = 5.76)(Z = 4.35)(Z = 7.37)
Lt. lingual gyrusRt. lingual gyrusLt. lingual gyrus
(−10, −90, −14)(18, −90, −10)(−22, −82, −22)
(Z = 7.62)(Z = 7.35)(Z = 8.00)
Lt. Fusiform gyrusLt. lingual gyrusRt. superior parietal lobe
(−38, −74, −16)(−16, −86, −14)(28, −74, 22)
(Z = 7.72)(Z = 8.00)(Z = 7.04)
Lt. inferior frontal gyrusRt. superior parietal lobeLt. superior parietal lobe
(−52, 28, 32)(28, −74, 18)(−20, −68, 38)
(Z = 5.72)(Z = 4.95)(Z = 7.82)
Rt. postcentral gyrusLt. superior parietal lobeRt. inferior temporal gyrus
(52, −14, 40)(−22, −66, 26)(54, −40, −14)
(Z = 4.75)(Z = 6.05)(Z = 4.54)
Lt. postcentral gyrusLt. inferior temporal gyrusLt. inferior temporal gyrus
(−44, −28, 58)(−56, −42, −14)(−54, −44, −22)
(Z = 5.36)(Z = 6.09)(Z = 7.38)
Rt. middle frontal gyrusLt. middle temporal gyrusRt. middle temporal gyrus
(42, 10, 52)(−44, −36, −4)(44, −28, −10)
(Z = 4.56)(Z = 7.01)(Z = 4.45)
Rt. Superior parietal lobeRt. inferior frontal gyrusLt. middle temporal gyrus
(14, −54, 54)(26, 32, −18)(−44, −36, −8)
(Z = 4.53)(Z = 3.72)(Z = 7.15)
Rt. cerebellumLt. middle frontal gyrusRt. inferior frontal gyrus
(20, −72, −18)(−44, 6, 50)(38, −12, 30)
(Z = 3.90)(Z = 7.09)(Z = 4.30)
Lt. inferior frontal gyrusLt. middle frontal gyrus
(−26, 30, −14)(−26, 0, 28)
(Z = 5.52)(Z = 8.00)
Lt. supplementary motor areaRt. cerebellum
(−8, 10, 60)(24, −56, −32)
(Z = 5.88)(Z = 8.00)
Rt. precentral gyrusLt. cerebellum
(60, −4, 32)(−24, −52, −34)
(Z = 5.79)(Z = 6.36)
Rt. cerebellum
(22, −72, −40)
(Z = 5.90)
(C) The finger-tapping task (six normal volunteers and the patient)
Lt. precentral gyrusPonsRt. precentral gyrus
(−24, −30, 66)(−6, −36, −38)(62, 2, 24)
(Z = 4.59)(Z = 5.22)(Z = 5.70)
Lt. Superior temporal gyrusRt. precentral gyrusLt. precentral gyrus
(−52, 8, 10)(60, −4, 28)(−30, −10, 64)
(Z = 3.62)(Z = 5.25)(Z = 6.88)
Lt. supplementary motor areaLt. precentral gyrusLt. supplementary motor area
(−6, −6, 68)(−30, −24, 42)(−8, 2 84)
(Z = 4.22)(Z = 6.94)(Z = 5.66)
Rt. cerebellumLt. inferior temporal gyrusLt. anterior cingulate
(22, −50, −20)(−40, −14, −26)(−6, −12 50)
(Z = 3.98)(Z = 5.92)(Z = 5.22)
Lt. superior temporal gyrusLt. inferior frontal gyrus
(−58, −26, 22)(−48, 10, 28)
(Z = 5.36)(Z = 5.01)
Rt. lingual gyrusRt. cerebellum
(18, −88, −6)(28, −50, −28)
(Z = 5.93)(Z = 6.40)
Rt. superior frontal gyrus
(20, 66 26)
(Z = 5.04)
Rt. superior occipital gyrus
(36, −74, 10)
(Z = 4.95)
Rt. cerebellum
(20, −56, −30)
(Z = 7.44)
Lt. cerebellum
(−20, −52, −32)
(Z = 8.00)