Table 4

‚ÄÉMajor congenital malformation rate for monotherapy exposure to carbamazepine, valproate, and lamotrigine by dose

AEDMaximum daily dose (mg)Total informative exposures (n)MCMs (n)MCM rate, % (95% CI)
AED, antiepileptic drug; CI, confidence interval; MCM, major congenital malformation.
Carbamazepine<40040171.7 (0.8 to 3.6)
400 to 1000385102.6 (1.4 to 4.7)
>10009233.3 (1.1 to 9.2)
Valproate<600266114.1 (2.3 to 7.3)
600 to 1000247156.1 (3.7 to 9.8)
>1000186179.1 (5.8 to 14.1)
Lamotrigine<10015121.3 (0.4 to 4.7)
100 to 20020841.9 (0.8 to 4.8)
>200279155.4 (3.3 to 8.7)