Table 1

 Demographic, clinical, and magnetic resonance imaging characteristics by diagnostic group

Controls (n = 73)FTLD (n = 42)AD (n = 103)
Values are mean (SD) or median (range). Raw hippocampal volumes are presented, but these were subsequently corrected for age, sex, intracranial area, and type of scanner. Analysis of variance (ANOVA) with post hoc Bonferroni tests was used unless stated otherwise.
*p<0.05 v controls; **p<0.01 v controls; ***p<0.01 v AD.
†Mann–Whitney U test.
‡CDR score was missing for one FTLD and one AD patient.
§Data on disease duration were missing for five AD patients.
¶Kruskal–Wallis test with post hoc Mann–Whitney U tests.
AD, Alzheimer’s disease; CDR, Clinical Dementia Rating scale; FTLD, frontotemporal lobar degeneration; ICA, intracranial area; MTA, medial temporal lobe atrophy.
Age (y)75 (8)65 (7)**/***71 (9)*
Sex (M:F)34:3926:1643:60
CDR†‡1.0 (0.5 to 3.0)1.0 (0.5 to 3.0)
Disease duration (y)†§6 (1 to 13)***3 (1 to 13)
ICA (cm2)146 (12)151 (11)*/***145 (11)
Left hippocampus (cm3)1.69 (0.21)1.43 (0.24)**1.37 (0.24)**
Right hippocampus (cm3)1.75 (0.19)1.61 (0.28)**1.46 (0.24)**
Left MTA¶1.34 (0.78)2.41 (0.94)**2.38 (0.84)**
Right MTA¶1.37 (0.77)2.07 (0.92)**2.39 (0.87)**