Parkinson’s disease | PSP | MSA | |||||||
---|---|---|---|---|---|---|---|---|---|
Fallers | Non-fallers | p Value | Early fallers | Early non-fallers | p Value | Fallers | Non-fallers | p Value | |
NS, not significant. | |||||||||
Number | 313 | 114 | 75 | 49 | 66 | 19 | |||
Gender (% female) | 43.1 | 27.2 | 0.002 | 36 | 40.8 | NS | 59 | 36.8 | NS |
Early clinical features | |||||||||
Cognitive dysfunction | 0 | 0 | NS | 70.7 | 28.6 | <0.001 | 4.8 | 0 | NS |
Tremor | 72.4 | 86.2 | 0.004 | 6.8 | 35.4 | <0.001 | 42.2 | 42.1 | NS |
Axial rigidity | 5.6 | 8.1 | NS | 54.7 | 32.5 | 0.024 | 16.7 | 5.9 | NS |
Limb rigidity | 75 | 81.9 | NS | 63.9 | 61.4 | NS | 61.1 | 68.9 | NS |
Asymmetric onset | 84.8 | 88.2 | NS | 34.8 | 83.1 | <0.001 | 60.3 | 50 | NS |
Postural instability | 8.7 | 1.9 | 0.017 | 91.9 | 41.9 | <0.001 | 28.6 | 21.1 | NS |
Vertical gaze palsy | 6.2 | 0 | NS | 54.9 | 11.5 | <0.001 | |||
Abnormal saccades | 12 | 0 | NS | 83.3 | 45.0 | 0.002 | |||
Speech disturbance | 9.6 | 6.5 | NS | 66.7 | 41.7 | 0.006 | 19.3 | 38.9 | NS |
Dysphagia | 0.7 | 2.9 | NS | 26.7 | 12.5 | NS | 4.9 | 17.6 | NS |
Pyramidal signs | 3.3 | 0 | NS | 12.3 | 15.2 | NS | 17.4 | 16.7 | NS |
Dyskinesias | 0.7 | 0.9 | NS | 0 | 0 | NS | 0 | 1.6 | NS |
Autonomic dysfunction | 5.7 | 3.6 | NS | 1.4 | 2.0 | NS | 55.6 | 58.9 | NS |
Late clinical features | |||||||||
Cognitive dysfunction | 71.7 | 49.5 | <0.001 | 31.6 | 12.5 | NS | |||
Tremor | 85.7 | 93.6 | 0.018 | 60.3 | 68.4 | NS | |||
Axial rigidity | 30.1 | 22.3 | NS | 47.5 | 41.2 | NS | |||
Limb rigidity | 98 | 98.2 | NS | 96.7 | 77.8 | 0.008 | |||
Postural instability | 45.6 | 83.8 | <0.001 | 94.7 | 88.2 | NS | |||
Speech disturbance | 78.8 | 59 | <0.001 | 98.4 | 82.4 | 0.007 | |||
Dysphagia | 59.7 | 46.9 | 0.033 | 94.9 | 68.8 | 0.003 | |||
Dyskinesias | 58.1 | 53.3 | NS | 22.2 | 22.2 | NS | |||
Autonomic dysfunction | 46.9 | 21.5 | <0.001 | 88.9 | 100 | NS | |||
Pyramidal signs | 5.4 | 9.4 | NS | 66.7 | 33.3 | 0.018 | |||
Hallucinations | 53.3 | 37.5 | 0.004 | 10.6 | 5.9 | NS |