Performance of the McDonald and modified criteria*† in optic neuritis and non-optic neuritis subgroups
| TP | FP | TN | FN | Sensitivity | Specificity | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| *TP, true positive (criteria positive and CDMS); FP, false positive (criteria positive and not MS); TN, true negative (criteria negative and not MS); FN, false negative (criteria negative and CDMS); sensitivity, TP/(TP+FN); specificity, TN/(TN+FP). | ||||||||||
| †Brain and spinal cord MRI findings are included, except that in patients with a brain stem or spinal cord syndrome, lesions in the symptomatic region (that is, infratentorial and spinal cord, respectively) were excluded. | ||||||||||
| CDMS, clinically definite multiple sclerosis; MRI, magnetic resonance imaging; MS, multiple sclerosis. | ||||||||||
| Optic neuritis | McDonald criteria for MS | 12 | 2 | 37 | 16 | 43% | 95% | |||
| Modified criteria for MS | 20 | 2 | 37 | 8 | 71% | 95% | ||||
| Non-optic-neuritis | McDonald criteria for MS | 6 | 1 | 11 | 5 | 55% | 92% | |||
| Modified criteria for MS | 10 | 2 | 10 | 1 | 91% | 83% | ||||