Performance of the McDonald and modified criteria*† for clinically definite multiple sclerosis in subgroups first scanned less than or more than six weeks after CIS onset
| TP | FP | TN | FN | Sensitivity | Specificity | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| *TP, true positive (criteria positive and CDMS); FP, false positive (criteria positive and not MS); TN, true negative (criteria negative and not MS); FN, false negative (criteria negative and CDMS); sensitivity, TP/(TP+FN); specificity, TN/(TN+FP). | ||||||||||
| †Brain and spinal cord MRI findings are included, except that in patients with a brain stem or spinal cord syndrome, lesions in the symptomatic region (that is, infratentorial and spinal cord, respectively) were excluded. | ||||||||||
| CDMS, clinically definite multiple sclerosis; CIS, clinically isolated syndrome; MRI, magnetic resonance imaging; MS, multiple sclerosis. | ||||||||||
| Patients scanned <6 weeks after CIS onset (n = 45) | McDonald criteria for MS | 8 | 2 | 26 | 9 | 47% | 93% | |||
| Modified criteria for MS | 13 | 2 | 26 | 4 | 76% | 93% | ||||
| Patients scanned >6 weeks after CIS onset (n = 45) | McDonald criteria for MS | 10 | 1 | 22 | 12 | 45% | 96% | |||
| Modified criteria for MS | 17 | 2 | 21 | 5 | 77% | 91% | ||||