Table 2 Key brain regions mediating human sexual behaviour
Key brain regionsSexual functionPsychosurgery/neurosurgery/stimulationSeizure relatedOther: case studiesNeuroimaging
Subcortical
    Septal regionPleasurable response and orgasmHeath (1964, 1972)7 8 Gorman (1992)10
    HypothalamusNeuroendocrine and autonomic aspects of sexual drive, sexual orientationRoeder (1972)14Poeck (1965)15, Ortego (1993)16Hamann (2004),18 Redoute (2000),19 Beauregard (2001),20 Ferretti (2005)21
    Ansa lenticularis and pallidusSexual drive alibido/ hypersexualityMeyers (1961, 1962),22 23 Mendez (2004)24
Cortical
    Frontal lobesMotor components of sexual behaviour, control of sexual response (disinhibition)Freeman (1943),27 Levine (1951)28Spencer (1983),30 Williamson (1985),31 Leutmetzer (1999)32Hamann (2004),18 Redoute (2000),19 Ferretti (2005),21 Tiihonen (1994),33 Karama (2002)34
    Parietal lobes: paracentral lobuleGenital sensationBates (1953),40 Penfield (1950)42Toone (1991, 1995),35 36 Ruff (1980),37 Erickson (1945),38 Bancaud (1970)39
    Temporal lobes: amygdalaSexual orientation, sexual disorders (eg, paraphilias), sexual drive (hypo/hypersexuality, impotence)Gloor (1986),85 Kim (1972)93Bancaud (1970),39 Mitchell (1954),50 Gastaut (1954),56 Blumer (1967),57 Remillard (1983),65 Baird (2003),76Terzian (1955),46 Marlowe (1975),47 Lilly (1983),48 Kolarsky (1967),54 Mendez (2000)55Hamann (2004),18 Redoute (2000),19 Beauregard (2001),20 Ferretti (2005),21 Baird (2004),83 Holstege (2003)89