Comparisons between risk factor profiles of cerebral small vessel disease, large vessel disease and normal control groups on multivariate analysis
| LVD vs controls | SVD vs controls | SVD vs LVD | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | |
| LVD, large vessel disease; MI, myocardial infarction; PVD, peripheral vascular disease; SVD, small vessel disease. | ||||||
| Multivariate analysis was performed using all risk factor variables in the table, with the exception of PVD, for comparisons involving the normal control group. OR, 95% CI and p values are shown. | ||||||
| Age (y) | 1.04 (1.02 to 1.05) | <0.001 | 1.03 (1.02 to 1.05) | <0.001 | 1.00 (0.99 to 1.02) | 0.649 |
| Male sex | 1.14 (0.87 to 1.49) | 0.354 | 1.25 (0.95 to 1.65) | 0.113 | 1.33 (0.97 to 1.81) | 0.076 |
| Hypertension | 1.46 (1.06 to 2.01) | 0.020 | 4.88 (3.34 to 7.15) | <0.001 | 3.43 (2.32 to 5.07) | <0.001 |
| Diabetes | 4.84 (2.71 to 8.66) | <0.001 | 2.74 (1.51 to 4.97) | 0.001 | 0.77 (0.51 to 1.17) | 0.215 |
| Hypercholesterolaemia | 2.76 (1.94 to 3.92) | <0.001 | 0.86 (0.62 to 1.19) | 0.363 | 0.34 (0.24 to 0.48) | <0.001 |
| Smoking | 3.64 (2.54 to 5.22) | <0.001 | 1.84 (1.32 to 2.57) | <0.001 | 0.63 (0.44 to 0.91) | 0.012 |
| MI | 2.89 (1.70 to 4.91) | <0.001 | 0.72 (0.36 to 1.44) | 0.354 | 0.35 (0.20 to 0.59) | <0.001 |
| PVD | – | – | – | 0.32 (0.20 to 0.50) | <0.001 | |