Table 1

 Blind assessment (offline video) of motor performance in the absence of l-dopa and following acute administration of l-dopa, before and after 3 months of methylphenidate treatment

Blind assessmentWithout MPDUnder MPD
Off l-dopaOn l-dopaOff l-dopaOn l-dopa
–, no assessment; MPD, methylphenidate; SWS, Stand–Walk–Sit Test; UPDRS, Unified Parkinson’s Disease Rating Scale.
The median values (1st quartile, 3rd quartile) are specified.
Significant differences in the completion time and the number of steps in the SWS Test and in the UPDRS part III score were observed when comparing the four conditions.
*Significant difference (p<0.05) before and after MPD, in the absence of l-dopa.
†Significant difference before and after MPD, when taking l-dopa (p<0.05).
SWS Test: Completion time25 (22, 33)19.5 (15, 28)20 (17, 29)*15.5 (13, 20]†
SWS steps38 (35, 44)29 (26, 35)30 (28, 37)*24 (22, 29)†
UPDRS part III34 (23.5, 43)*30.5 (18.5, 36)†29 (22.5, 33.5)*21 (16, 27)†
Tinetti Scale score8 (7, 10)*10 (9, 11)†8.5 (7.5, 11)*11 (10, 12)†
Dyskinesia Rating Scale score0 (0, 1)2 (0, 5.5)0 (0, 1)3.5 (0, 4)
Freezing in off l-dopa and on l-dopa conditions7 patients7 patients5 patients4 patients
Number of episodes1.5 (1, 2)1 (1, 1.5)1.5 (0.25, 2.5)0.5 (0, 1)
Only off l-dopa freezing4 patients0 patient0 patient
Number of episodes0.5 (0.5, 0.75)0*0†
Only on l-dopa freezing1 patient1 patient1 patient
Number of episodes121.5