Table 2

 Open-label assessment of the motor, the cognitive and the psychiatric performances on the Unified Parkinson’s Disease Rating Scale part I and II, the Epworth Sleepiness Scale, the Montgomery Asberg Depression Rating Scale score, the Brief Psychiatric Rating Scale and the Lille Apathy Rating Scale

Open-labelassessmentBefore MPD treatmentAfter 3 monthson MPD
BPRS, Brief Psychiatric Rating Scale; CRT, choice reaction time; ESS, Epworth Sleepiness Scale; LARS, Lille Apathy Rating Scale; MADRS, Montgomery Asberg Depression Rating Scale; MPD, methylphenidate; SRT, simple reaction time; UPDRS, Unified Parkinson’s Disease Rating Scale.
Maintained attention (SRT and number of errors) and selective attention (CRT and number of errors) were analysed according to the global cognitive efficiency on the Mattis score before MPD treatment (for patients with a Mattis score ⩾130 and those with a Mattis score <130). The median values (1st quartile, 3rd quartile) are specified.
*Significant difference (p<0.05).
UPDRS part I4 (3, 5)3 (2, 4)*
UPDRS part II21 (6.75, 24)19 (19, 22)*
ESS7 (6, 10)6 (3, 6)*
MADRS8 (7, 13)8 (6, 12)
BPRS33 (30, 38.5)32 (28, 36)
LARS−21 (−26, −19)−21 (−25, −14)
Sustained attention
    Mattis score ⩾130SRT 643 (630, 774)SRT 641 (588, 710)*
Errors 0(0, 0)Errors 0(0, 0)
    Mattis score <130SRT 643 (595, 731)SRT 747 (635, 1184)
Errors 0(0, 0)Errors 0(0, 0)
Selective attention
    Mattis score ⩾130CRT 935 (744, 994)CRT 900 (836, 1010)
Errors 0(0, 0.5)Errors 0(0, 2)
    Mattis score <130CRT 900 (898, 939)CRT 1104 (904, 1364)*
Errors 0 (0, 0.75)Errors 0 (0, 3)