Table 1

 Brain regions exhibiting diffusion and voxel based morphometry abnormalities

Cortical areaSideMNI coordinates x, y, zT scorep Value
ALSFRS, Amyotrophic Lateral Sclerosis Functional Rating Scale; Ant, anterior; FA, fractional anisotropy; GM, grey matter; L, left; MD, mean diffusivity; Post, posterior; R, right; WM, white matter.
Coordinates are in MNI space. Only the higher peaks per region are given. Uncorrected clusters are shown in italics.
Group comparison: decreased FA
    Corticospinal tract underneath motor cortexR40, −24, 445.350.012
R36, −14, 444.110.029
R38, −8, 363.870.041
L−30, −20, 425.550.012
    Corticospinal tract in centrum semiovaleL−18, −22, 305.980.012
L−24, −22, 485.410.012
R20, −22, 423.940.037
    Corticospinal tract in the internal capsuleL−18, −20, −64.750.015
    WM underneath motor cortex (medial part)R14, −22, 524.690.016
    Thalamus0, −18, 124.540.018
    WM underneath parietal cortexR42, −44, 285.010.013
L 44,50, 28 3.70 0.051
    InsulaL−42, −2, 24.400.021
    WM underneath ventrolateral premotor cortexL−42, −8, 183.850.042
R 40, 10,2 3.68 0.052
Group comparison: increased MD
    Precentral gyrus (primary motor cortex)R48, −10, 2060.023
L−44, −16, 205.210.029
    Ventrolateral premotor cortex/insula (post part)R42, 18, 24.280.048
L−46, 14, 04.640.042
    Ventrolateral premotor cortex/insula (ant part)L−34, 28, −24.410.047
    Superior temporal gyrusR60, −26, 124.770.036
R50, −54, 24.170.048
    Corticospinal tract in centrum semiovaleL−24, −20, 424.290.048
R30, −18, 384.280.048
    Hippocampal formationR32, −20, −144.010.048
L−30, −14, −183.920.049
Positive correlation between FA and ALSFRS
    WM underneath the lateral part of the precentral gyrusR40, 4, 187.664568
    Corticospinal tract in centrum semiovaleR30, −8, 326.15
L−26, −16, 384.87
    Corticospinal tract underneath motor cortexL−18, −10, 583.04
R28, −32, 562.19
    InsulaL−42, −6, 44.45
L−30, 20, 63.48
    WM underneath ventrolateral premotor cortexR50, 16, 42.29
L−46, 18, −43.20
    PrecuneusL−14, −60, 324.58
    Cingulum (posterior part)L−14, −42, 303.18
    Corpus callosumR10, −22, 304.05
L−4, −16, 283.07
Group comparison: decreased GM volume
    Hippocampal formationL−18, −28, −105.040.034
R30, −34, −64.340.034
    Temporal isthmusL−22, −52, −104.500.034
R28, −44, −104.960.034
    ThalamusR6, −22, −24.340.034
L−12, −14, 163.330.046
    Inferior frontal gyrusL−48, 16, 223.460.043
R44, 10, 343.310.046
    Precentral gyrus (primary motor cortex)L−56, −18, 284.520.034
L−34, −34, 583.710.037
R42, −24, 523.800.036
    Ventrolateral premotor cortex/insula (post part)L−54, −2, 43.710.037
    Ventrolateral premotor cortex/insula (ant part)L−48, 18, −24.770.034
R 50, 20, 2 3.18 0.052
    Parietal cortexL−34, −54, 483.580.040
    Occipital lobeL−20, −72, −124.360.034
    CerebellumR10, −56, −143.820.036
    Superior temporal gyrusL−54, −20, 124.920.034
    Superior temporal sulcusL−52, −56, 163.900.036