Table 1 Clinical features of POEMS syndrome

Case	Age/Sex	Organomegaly	Endocrinopathy	M-protein	Skin change	Bone lesion	VEGF level* (pg/ml)	Cerebrospinal fluid protein (mg/dl)
1	43/W	CM, HM, SM, LA	–	IgAλ	HP, HT	Sclerotic	1310	93
2	68/W	CM, HM, SM	–	IgAλ	HP, HT	Sclerotic	2290	63
3	47/W	HM, SM	–	IgGλ	HP	–	1670	38
4	47/W	CM, HM, SM, LA	Hy	IgAλ	HP, HT	–	>2000	95
5	31/M	HM, SM	Gy, Im	IgGλ	HP, HT	Sclerotic, lytic	5500	130
6	54/W	HM, LA	–	IgGκ	HP, HT	Sclerotic	756†	107
7	48/M	LA	Gy	IgGλ	HP	Sclerotic	1830	63
8	46/M	HM, LA	Gy	IgGλ	HP	Sclerotic	>2000	108
9	62/M	SM	Gy	IgAλ	HP, HT	Sclerotic	>2000	165
10	58/M	–	Im	IgAλ	HP, HT	Sclerotic	>2000	53
11	57/W	CM, HM, SM	Hy	IgAλ	HP, HT	Sclerotic	>2000	179
12	28/W	HM, SM	–	IgGλ	HP, HT	Sclerotic, lytic	1120	238
13	72/M	HM, SM	Gu	IgGλ	HP	–	ND	124
14	67/W	CM, SM, LA	Hy	IgGλ	HP	–	>2000	97
15	63/M	HM, SM, LA	Hy, Gy, Im	IgGλ	HP, HT	–	ND	82
16	45/M	LA	Gu, Hy, Im	IgAλ	HP, HT	–	ND	196
17	69/W	ND	–	IgAλ	HP	–	ND	108
18	60/M	LA	Hy	IgAλ	HP, HT	–	ND	62
19	63/M	SM	Im	–	HP	Sclerotic	814†	78
20	45/M	HM	Gu, Gy	–	HP, HT	–	1280	360
21	85/M	CM, HM, SM, LA	Gy	IgAλ	HP	–	500†	57
22	47/M	HM, SM	Im	IgGλ	HP, HT	Lytic	1280	81

VEGF, vascular endothelial growth factor (normal<707 pg/ml for serum, <115 pg/ml for plasma); –, abscent; CM, cardiomegaly; Gu, glucose intorelance; Gy, gynecomastia; HM, hepatomegaly; HP, hyperpigmentation; HT, hypertrichosis; Hy, hypothyroidism; Im, impotence; LA, lymphadenopathy; ND, not determined; POEMS, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes; SM, splenomegaly.
*Serum VEGF levels were measured except in patients 6, 19 and 21.
†Plasma VEGF levels were measured.