Table 1 Various neurophysiological criteria for the diagnosis of Guillain–Barre syndrome
Conduction velocity in m/sDistal latency (ms)Temporal dispersionConduction blockF wave latency (ms)
Set 1 must have one abnormality in two nerves<95% if amp >50%; <85% if amp <50%>110% if amp normal; >120% if amp <normalProx-dist duration increase 30% orProx-dist amp ratio <0.7>120%
Set 2 must have 3 abnormalities<80% if amp >80%; <70% if amp <80% (2 nerves)>125% if amp >80%; >150% if amp <80% (2 nerves)>20% NP amp or NP area decrease prox-dist; >15% prox-dist duration increase (one or more nerves) or>20% NP amp or NP area decrease prox-dist (one or more nerves)>120% if amp >80%; >150% if amp <80% (2 nerves)
Set 3 must have one abnormality in 2 nerves<90% if amp >50%; <85% if amp <50%>110% if amp normal; >120% if amp <normalProx-dist dur increase 30%>120%
Set 4 must have one in 2 nerves<70%>150%Dist-prox dur ratio >150% upper limit of normal; distal dur >300% upper limit of normalAmp decrease >upper limit of normal>150%
Set 5 must have 2 abnormalities<80% if amp >80%; <70% if amp <80% (2 nerves)>125% if amp >80%; >150% if amp <80% (2 nerves)Prox-dist dur increase 30%Prox-dist amp ratio <0.7>120% if amp >80%; >150% if amp <80% (2 nerves)
Set 6 must have 3 abnormalities<90% if amp >50%; <80% if amp <50% (2 nerves)>115% if amp normal; >125% if amp <normal (2 nerves)Prox-dist dur increase 30% (one or more nerves) orProx-dist amp ratio <0.7 (one or more nerves)>125% (one or more nerves)
  • Set 1, Albers and colleagues2; set 2, Cornblath3; set 3, Ho and colleagues4; set 4, Dutch GBS study group5; set 5, Italian GBS study group6; set 6, Albers and Kelly.7

  • amp, compound muscle action potential amplitude; dist, distal; dur, duration; NP, negative peak; prox, proximal.