Patient No | Clinical diagnosis | Diagnosis on clinical research criteria or at post mortem | Notes |
23 | PD with coexistent Alzheimer’s disease | DLB | Mild to moderate dementia developing 3 y before onset of asymmetric parkinsonism with tremor. Dementia diagnosed as Alzheimer’s disease by psychiatrists. No fluctuating confusion or hallucinations. |
24 | PD | MSA | Asymmetric bradykinesia and rest tremor. Yet to undergo full trial of dopaminergic therapy. Otherwise unexplained urinary urgency and incontinence. |
25 | PD | MSA | Asymmetric parkinsonism, dominated by tremor. Postural hypotension prior to dopaminergic therapy. Mediocre response to levodopa. |
26 | PD | PSP* | Typical asymmetric rest tremor. Poor levodopa response. No gaze palsy. Early balance problems, attributed to hip fracture. Post-mortem diagnosis of progressive supranuclear palsy. |
27 | PD | PSP* | Asymmetric parkinsonism with tremor. No gaze palsy. Poor objective response to levodopa, but assessment made difficult by previous stroke. Early balance problems, attributed to stroke. Post-mortem diagnosis of progressive supranuclear palsy. |
28 | PD | Parkinsonism, unspecified | Unilateral parkinsonism with rest tremor, remaining unilateral after 4 y of follow-up. FP-CIT in keeping with degenerative parkinsonian syndrome. MRI brain scan normal. |
29 | DLB | PD | First onset of symptoms in 2001. Onset of dementia with fluctuating confusion and hallucinations in 2004, quickly coming to dominate clinical picture. |
30 | DLB | Vascular parkinsonism | Asymmetric bradykinesia and rest tremor affecting face and left hand. Dementia with fluctuations in confusion but no hallucinations. MRI brain showed extensive ischaemia. FP-CIT SPECT scan atypical. |
*Did not meet research diagnostic criteria prior to post mortem.
DLB, dementia with Lewy bodies; FP-CIT SPECT, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)-tropane single photon emission computed tomography; MSA, multiple system atrophy; PD, Parkinson’s disease; PSP, progressive supranuclear palsy.