Table 5 Differences between latest clinical diagnosis and diagnosis on research criteria
Patient NoClinical diagnosisDiagnosis on clinical research criteria or at post mortemNotes
23PD with coexistent Alzheimer’s diseaseDLBMild to moderate dementia developing 3 y before onset of asymmetric parkinsonism with tremor. Dementia diagnosed as Alzheimer’s disease by psychiatrists. No fluctuating confusion or hallucinations.
24PDMSAAsymmetric bradykinesia and rest tremor. Yet to undergo full trial of dopaminergic therapy. Otherwise unexplained urinary urgency and incontinence.
25PDMSAAsymmetric parkinsonism, dominated by tremor. Postural hypotension prior to dopaminergic therapy. Mediocre response to levodopa.
26PDPSP*Typical asymmetric rest tremor. Poor levodopa response. No gaze palsy. Early balance problems, attributed to hip fracture. Post-mortem diagnosis of progressive supranuclear palsy.
27PDPSP*Asymmetric parkinsonism with tremor. No gaze palsy. Poor objective response to levodopa, but assessment made difficult by previous stroke. Early balance problems, attributed to stroke. Post-mortem diagnosis of progressive supranuclear palsy.
28PDParkinsonism, unspecifiedUnilateral parkinsonism with rest tremor, remaining unilateral after 4 y of follow-up. FP-CIT in keeping with degenerative parkinsonian syndrome. MRI brain scan normal.
29DLBPDFirst onset of symptoms in 2001. Onset of dementia with fluctuating confusion and hallucinations in 2004, quickly coming to dominate clinical picture.
30DLBVascular parkinsonismAsymmetric bradykinesia and rest tremor affecting face and left hand. Dementia with fluctuations in confusion but no hallucinations. MRI brain showed extensive ischaemia. FP-CIT SPECT scan atypical.
  • *Did not meet research diagnostic criteria prior to post mortem.

  • DLB, dementia with Lewy bodies; FP-CIT SPECT, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)-tropane single photon emission computed tomography; MSA, multiple system atrophy; PD, Parkinson’s disease; PSP, progressive supranuclear palsy.