Table 5 Grey matter correlations with clinical metrics
MetricVBM grey matter correlationWhole nGMV correlation
Clusterp ValueRegionMNI
Cerebellar score16050.018Left cerebellum−42 −72 −26NS
530.019Right cerebellum44 −63 −27
NHPT (z res)36050.002Right cerebellum32 −58 −32NS
29460.002Left cerebellum−42 −65 −41
930.002Left cerebellum−41 −67 −52
T1LV10840.020Left thalamus−9 −13 14NS
5740.037Right thalamus8 −12 8
3680.037Left hippocampus−31 −26 −11
MSFC38820.002Right cerebellum33 −63 −30NS
35480.002Left cerebellum−27 −69 −32
4320.002Right caudate10 11 −11
2360.002Left putamen−29 4 −1
940.002Left cerebellum−35 −79 −41
590.003Left claustrum−32 1 −7
Disease durationNSNSNSNS
Pyramidal scoreNSNSNSNS
  • 25FWT, 25-Foot Timed Walk; EDSS, Expended Disability Status Score; MSFC, Multiple Sclerosis Functional Composite; nGMV, normalised grey matter volume; NHPT, 9-Hole Peg Test; NS, not significant with p>0.05; p, voxel p-value with FDR-correction for multiple comparisons; PASAT, Paced Auditory Serial Addition Test - 3; TILV, T1 brain lesion volume; VBM, voxel-based morphometry; z-res, z-residuals.