Table 5 Grey matter correlations with clinical metrics

Metric	VBM grey matter correlation				Whole nGMV correlation
Metric	Cluster	p Value	Region	MNI	Whole nGMV correlation
Cerebellar score	1605	0.018	Left cerebellum	−42 −72 −26	NS
	53	0.019	Right cerebellum	44 −63 −27
NHPT (z res)	3605	0.002	Right cerebellum	32 −58 −32	NS
	2946	0.002	Left cerebellum	−42 −65 −41
	93	0.002	Left cerebellum	−41 −67 −52
25FWT (z res)	NS	NS	NS		NS
PASAT (z res)	NS	NS	NS		NS
T1LV	1084	0.020	Left thalamus	−9 −13 14	NS
	574	0.037	Right thalamus	8 −12 8
	368	0.037	Left hippocampus	−31 −26 −11
MSFC	3882	0.002	Right cerebellum	33 −63 −30	NS
	3548	0.002	Left cerebellum	−27 −69 −32
	432	0.002	Right caudate	10 11 −11
	236	0.002	Left putamen	−29 4 −1
	94	0.002	Left cerebellum	−35 −79 −41
	59	0.003	Left claustrum	−32 1 −7
EDSS	NS	NS	NS		NS
Disease duration	NS	NS	NS		NS
Pyramidal score	NS	NS	NS		NS

25FWT, 25-Foot Timed Walk; EDSS, Expended Disability Status Score; MSFC, Multiple Sclerosis Functional Composite; nGMV, normalised grey matter volume; NHPT, 9-Hole Peg Test; NS, not significant with p>0.05; p, voxel p-value with FDR-correction for multiple comparisons; PASAT, Paced Auditory Serial Addition Test - 3; TILV, T1 brain lesion volume; VBM, voxel-based morphometry; z-res, z-residuals.