Table 1 Demographic and clinical features of patients with primary late-onset dystonia according to the site of dystonia onset
Presentation of dystonia
Blepharospasm (n = 124)Cervical dystonia (n = 73)Focal hand dystonia (n = 26)
Age, years (SD)70.7 (8.9)60 (13)55.2 (11.6)
Sex, male/female30/9424/4914/12
Age of onset, years (SD)55.9 (10.7)41.7 (13.9)39.1 (12.6)
Period of follow-up, years (SD)14.9 (4.9)16.3 (5.0)14.8 (4.5)
No of patients (%) who58 (47%)*17 (23%)10 (38%)
experienced spread
Spread to only one body site
No of patients (%)46 (37)13 (18)6 (23)
Age of spread, years (SD)59.9 (10.6)§50.6 (11.3)52.4 (11.1)
Time to spread, years (SD)4.5 (5.6)9.3 (8.5)14.8 (11.6)
Spread to a second body site
No of patients (%)12 (10)4 (5)4 (15)
Age of spread, years (SD)65.3 (8.5)48 (4.0)56.2 (6.6)
Time from 1st to 2nd spread, years (SD)6.3 (4.5)8 (2.0)2.7 (3.0)
  • Chi square (2 × 3): *p<0.001.

  • One-way ANOVA: F = 36, p<0.001; Newman–Keuls post-hoc test: blepharospasm different from other groups, p<0.05. F = 13.8, p<0.001; Newman–Keuls post-hoc test: blepharospasm different from other groups, p<0.05. §F = 6.12, p = 0.004; Newman–Keuls post-hoc test: blepharospasm different from other groups, p<0.05. F = 4.79, p = 0.02; Newman–Keuls post-hoc test: blepharospasm different from other groups, p<0.05.