PD | PSP | MSA | VP | DLB | UP | Disease control | Control | |
n | 115 | 22 | 9 | 5 | 5 | 19 | 15 | 14 |
Age (y) (range) | 65 (35–85) | 68.2 (58–78) | 60.5 (53–69) | 74.8† (62–92) | 74.2 (64–80) | 66.6 (20–82) | 67.4 (50–87) | 62.6 (42–76) |
Disease duration (y) (range) | 10.0 (1–27) | 4.8† (2–15) | 6.7 (2–13) | 6.6 (3–13) | 6.9 (3–17) | 7.9 (0.3–22) | 20.8† (4–55) | – |
Sex (M:F) (%) | 70:30 | 59:41 | 33:67* | 20:80* | 80:20 | 53:47 | 53:47 | 50:50 |
L-dopa | 82 | 52* | 44* | 60 | 80 | 61* | 7* | 0* |
Dopamine agonists | 60 | 10* | 22* | 0* | 0* | 28* | 0* | 0* |
Amantadine | 41 | 32 | 44 | 40 | 20 | 6* | 0* | 0* |
Benzodiazepine | 0 | 0 | 0 | 0 | 0 | 0 | 27* | 0 |
L-dopa equivalent units (range) | 619 (0–3000) | 250 (0–750) | 407 (0–1050) | 381 (0–1100) | 0 | 453 (0–1100) | 0 | 0 |
MMSE (range) | 27.7 (13–30) | 25.9† (19–30) | 25.8† (22–230 | 28.5 (27–30) | 21.8† (17–28) | 24.9† (0–30) | 28.5 (26–30) | – |
UPDRS II (range) | 13.1 (2–30) | 15 (6–21) | 22† (10–32) | 15 (0–30) | 13.6 (8–24) | 11.7 (0–26) | 2.1† (0–8) | – |
UPDRS III (range) | 28.8 (7–60) | 33.9 (14–60) | 35 (31–42) | 33 (3–55) | 36.2 (24–60) | 28.4 (4–74) | 4.2† (0–13) | – |
H&Y (range) | 2.5 (1–5) | 3.4† (2–4) | 4† (2–5) | 2.8 (1–4) | 3 (2–4) | 2.5 (1–5) | 1 (0–2) | – |
QSVHI questions | ||||||||
A Screen | 38 | 0* | 0* | 0 | 80 | 21 | 0* | 14 |
B1 Presence | 46 | 9* | 0* | 20 | 100* | 22* | 11 | 0 |
B2 Passage | 52 | 5* | 0* | 0* | 80 | 28* | 33 | 7* |
B3 Illusions | 47 | 5* | 0* | 20 | 50 | 11* | 33 | 0 |
B Total | 72 | 9* | 0* | 20 | 100* | 37* | 33 | 7* |
C1 Formed VH | 38 | 0* | 0* | 20 | 60 | 11* | 0* | 0 |
C2 VH +AH | 6 | 0 | 0 | 0 | 20 | 0 | 0 | 0 |
Total VH | 75 | 14* | 0* | 20 | 100* | 47 | 56 | 7* |
E1 VH + delirium | 5 | 0 | 0 | 0 | 20 | 0 | 0 | 0 |
E2 Med related | 2 | 9 | 0 | 0 | 0 | 0 | 33 | 0 |
Total VH - E | 68 | 5* | 0* | 20 | 80 | 47* | 22 | 7* |
Medication use and QSVHI responses are expressed in per cent.
*Compared with PD, χ2 or Fisher’s exact p<0.05; †compared with PD, t test p<0.05.
AH, auditory hallucinations; DLB, dementia with Lewy bodies; H&Y, Hoehn and Yahr score; Med, medication; MMSE, Mini-Mental State Examination; MSA, multiple system atrophy; NR, not recorded; PD, Parkinson’s disease; PSP, progressive supranuclear palsy; QSVHI, Queen Square Visual Hallucination Inventory; UP, unclassifiable parkinsonism; UPDRS, Unified Parkinson’s Disease Rating Scale; VH, visual hallucinations; VP, vascular parkinsonism.