Table 2 Baseline MRI characteristics of patients and normal controls

Characteristics	Patients with MS, n = 147, median (range)	Normal controls, n = 27, median (range)	p Value
NBV, mm³	1500820 (1313270–1681271)	1538488 (1304801–1625547)	0.002
NGMV, mm³	804343 (593018–968991)	820923 (687035–883450)	0.160
NWMV, mm³	706960 (603196–788927)	721015 (617766–809745)	0.014
NPGV, mm³	596753 (450838–743511)	615155 (503224–658678)	0.002
3VW, mm	4 (1–14)	3 (2–9)	0.2
LVV, mm³	11880 (3465–50115)	11142 (3789–57612)	0.382
T2-LV, mm³	5330 (135–58335)	NA	–

The comparison between MS patients and the normal controls group was performed using General Linear Model, adjusting for baseline age and sex. Values are given as medians (range). 3VW, third ventricle width; LVV, lateral ventricle volume; MS, multiple sclerosis; NA, not available; NBV, normalised brain volume; NGMV, normalised grey matter volume; NPGV, normalised peripheral grey volume; NWMV, normalised white matter volume; T2-LV, T2-lesion volume.