| Months | 0–12 | 0–24 | 0–36 | 0–48 | 0–60 |
| n = 147 | n = 147 | n = 66 | n = 51 | n = 43 | |
| PBVC, % | −0.61 | −1.22 | −2.15 | −2.66 | −4.21 |
| GMV, mm3 (%) | −16754.7 (−2.1) | −21361.5 (−2.6) | −32427.9 (−4.2) | −34478.8 (−4.5) | −45752.6 (−6.2) |
| WMV, mm3 (%) | −1083.9 (−0.2) | 5068.2 (0.7) | 1257.7 (0.2) | −10921.1 (−1.6) | −3344.4 (−0.5) |
| PGV, mm3 (%) | −10367.3 (−1.8) | −14334.6 (−2.4) | −23884.4 (−4) | −27812.4 (−4.8) | −34389.1 (−5.8) |
| T2-LV, mm3 (%) | 327.5 (7.2) | 1225.75 (27.6) | 3130 (57.4) | 3315 (44.4) | 3015 (42) |
| 3VW, mm3 (%) | 0.08 (1.9) | 0.7 (9.3) | 0.52 (16.8) | 0.08 (2.3) | 0.12 (4) |
| LVV, mm3 (%) | 1017 (7.7) | 1878 (16.6) | 4035 (32.8) | 5403 (49.8) | 7062 (68.7) |
3VW, third ventricle width; GMV, grey matter volume; LVV, lateral ventricle volume; n, number of patients; PBVC, percentage brain volume change; PGV, peripheral grey volume; T2-LV, T2 lesion volume; WMV, white matter volume.