| Months | 0–12 | 0–24 | 0–36 | 0–48 | 0–60 |
| n = 36 | n = 36 | n = 36 | n = 36 | n = 36 | |
| PBVC, % | −0.91 | −1.41 | −2.52 | −2.8 | −3.65 |
| GMV, mm3 (%) | −11198.5 (−1.4) | −16993.9 (−2.3) | −20788.6 (−2.5) | −33375.1 (−4.4) | −44417 (−5.9) |
| WMV, mm3 (%) | −3145.9 (−0.4) | −3132 (−0.5) | 616.3 (0.1) | −5507.5 (−0.8) | 3492.9 (0.5) |
| PGV, mm3 (%) | −10824.1 (−1.8) | −11338 (−2.1) | −22442 (−3.6) | −28636.3 (−4.9) | −29637.2 (−5.5) |
| T2-LV, mm3 (%) | 390.5 (5.1) | 1968.5 (24.7) | 2765 (33.5) | 2180 (41.8) | 2605 (48.8) |
| 3VW, mm3 (%) | 0.11 (2.3) | 0.88 (10.9) | 0.97 (22.2) | 0.09 (2.4) | 0.1 (2.3) |
| LVV, mm3 (%) | 1284 (13.8) | 2838 (24.7) | 4680 (37.6) | 6091.5 (53.8) | 7146 (58.3) |
3VW, third ventricle width; GMV, grey matter volume; LVV, lateral ventricle volume; n, number of patients; PBVC, percentage brain volume change; PGV, peripheral grey volume; T2-LV, T2 lesion volume; WMV, white matter volume.