Table 5 Partial correlation analysis between PBVC and T2-LV changes at different time points adjusted for age at baseline MRI scan

		PBVC 0–12	PBVC 0–24	PBVC 0–36	PBVC 0–48	PBVC 0–60
T2-LV 0–12	r	0.042	−0.258	−0.273	−0.457	−0.442
	p Value	0.856	0.259	0.231	0.037	0.045
T2-LV 0–24	r	−0.413	−0.478	−0.675	−0.712	−0.793
	p Value	0.063	0.028	0.001	<0.001	<0.001
T2-LV 0–36	r	−0.350	−0.443	−0.558	−0.583	−0.601
	p Value	0.119	0.044	0.009	0.006	0.004
T2-LV 0–48	r	−0.316	−0.410	−0.628	−0.667	−0.679
	p Value	0.163	0.065	0.002	0.001	0.001
T2-LV 0–60	r	−0.361	−0.419	−0.475	−0.506	−0.503
	p Value	0.107	0.058	0.030	0.019	0.020

n, number of patients; PBVC, percentage brain volume change; r = partial correlation coefficient; T2-LV, T2 lesion volume change.