| Characteristic | MCI(n = 2879) | Normal(n = 4013) | p Value* |
| Age (years) | 74.6 (5.7) | 73.1 (4.9) | <0.01 |
| Sex (women) | 64.6 | 56.6 | <0.01 |
| Education level | |||
| Low | 24.7 | 22.5 | <0.01 |
| Medium | 62.2 | 54.2 | |
| High | 13.1 | 24.3 | |
| Hypertension† | 78.6 | 76.5 | 0.04 |
| Hypercholesterolaemia‡ | 59.0 | 57.2 | 0.15 |
| Diabetes mellitus | 11.0 | 9.0 | <0.01 |
| Head trauma | 7.5 | 7.2 | 0.21 |
| All cardiovascular antecedents | 10.0 | 7.7 | <0.01 |
| Stroke | 5.1 | 2.8 | <0.01 |
| Asthma | 8.5 | 7.5 | 0.13 |
| Depression | |||
| Current major depression | 2.4 | 1.6 | <0.01 |
| Depressive symptomatology | 16.0 | 10.3 | <0.01 |
| Subthreshold depression | 9.2 | 4.6 | <0.01 |
| Antidepressive drugs | 9.2 | 4.6 | <0.01 |
| ApoE4 genotype | 20.6 | 19.5 | 0.29 |
| NART | 21.1 (6.5) | 24.3 (5.4) | <0.01 |
| Anticholinergic drugs | 10.1 | 5.5 | <0.01 |
| At least 2 cups coffee/day | 65.8 | 67.9 | 0.03 |
| Tobacco use (packets/year) | 7.4 (16.4) | 8.6 (16.6) | <0.01 |
| Alcohol use | 78.8 | 81.4 | <0.01 |
| Physical activity | 31.5 | 36.5 | <0.01 |
| Good subjective health | 94.2 | 97.0 | <0.01 |
| Herpes | 30.7 | 30.1 | 0.57 |
| Insomnia | 28.5 | 21.8 | <0.01 |
| BMI >27 | 35.4 | 31.0 | <0.01 |
| Appetite loss | 14.2 | 10.7 | <0.01 |
| Social isolation | 37.6 | 35.8 | 0.06 |
| Difficulty with at least 1 IADL | 12.0 | 7.8 | <0.01 |
| Anaesthesia | 34.6 | 3.0 | 0.02 |
| Hospitalisation for cancer | 1.4 | 1.6 | 0.54 |
| HRT (past or current) | 30.2 | 33.0 | 0.06 |
All values are mean (SD) or percentage.
*Student t test or χ2 test as appropriate.
†Blood pressure cut-off 140/90 or antihypertensive treatment.
‡Cholesterol concentration 6.2 mmol/l or treatment.
BMI, body mass index; HRT, hormone replacement therapy; IADL, Instrumental Activities of Daily Living; NART, National Adult Reading Test.