Table 1

Baseline demographic and clinical findings in patients with and without apathy

All patientsApathyNo apathyp Value
(n = 79)(n = 11)(n = 68)
Female, n (%)44 (55.7)7 (63.6)37 (54.4)0.746
Age in years (SD)72.0 (8.3)73.4 (8.4)71.8 (8.3)0.533
Education in years (SD)9.3 (3.3)9.0 (2.7)9.3 (3.4)0.733
Disease duration in years (SD)13.0 (4.7)14.2 (4.4)12.8 (4.8)0.297
Total UPDRS motor score (SD)28.5 (17.6)23.8 (10.2)29.3 (18.5)0.650
UPDRS motor subscore A (SD)18.4 (12.3)14.5 (6.9)19.0 (12.9)0.436
UPDRS motor subscore B (SD)7.2 (4.5)7.5 (3.7)7.2 (4.7)0.594
Hoehn and Yahr stage
    Mean (SD)3.0 (0.9)3.2 (0.6)3.0 (1.0)0.306
    Range1.0–5.02.5–4.01.0–5.0
Montgomery and Aasberg Depression Rating Scale score (SD)5.4 (6.7)13.3 (7.3)4.2 (5.6)<0.001
Mini-Mental State Examination score (SD)25.5 (6.4)21.1 (6.7)26.2 (6.1)0.011
Neuropsychiatric Inventory apathy score (SD)1.2 (2.9)7.9 (2.6)0.1 (0.6)<0.001
Depression, n (%)16 (20.3)6 (54.5)10 (14.7)0.007
Dementia, n (%)23 (29.1)7 (63.6)16 (23.5)0.012
Levodopa equivalent dose, mg daily (SD)658 (387)630 (415)663 (386)0.456
Antidepressants, n (%)14 (17.7)3 (27.3)11 (16.2)0.370
Anxiolytics, n (%)7 (8.9)1 (9.1)6 (8.8)0.999
Antipsychotics, n (%)9 (11.4)3 (27.3)6 (8.8)0.084
  • Data are expressed as mean (SD) or number (percentage of assessed patients); all available data included. Comparisons between patients with and without apathy: χ2 tests or Fisher exact tests when appropriate for categorical variables, Mann–Whitney tests for continuous variables. All p values are two-tailed.

  • UPDRS, Unified Parkinson Disease Rating Scale.