Case No | Age (years) | Sex | Age at onset | Onset symptom | Charcot joint | CN | MNSI history | MNSI status | Cranial nerve | Muscle | Motor sign | Reflexes leg | Sensation | Other diagnosis | Clinical CTS | Nerve biopsy | ||||
Pinprick | Touch | Heat | Cold | Vibration | ||||||||||||||||
1 | 13 | M | N | 1 | 0 | N | N | N | + | ++ | ++ | ++ | ++ | ++ | N | |||||
2 | 16 | F | N | 0 | 0 | N | N | N | + | ++ | ++ | ++ | ++ | ++ | Or | N | ||||
3 | 16 | M | N | 1 | 1 | N | N | N | + | ++ | ++ | ++ | ++ | ++ | N | |||||
4 | 19 | F | N | 1 | 0 | N | N | N | + | ++ | ++ | ++ | ++ | ++ | N | |||||
5 | 20 | M | N | 0 | 0 | Pt | N | N | + | ++ | ++ | ++ | ++ | ++ | N | |||||
6 | 24 | M | N | 0 | 0 | N | N | N | + | ++ | ++ | ++ | ++ | ++ | N | |||||
7 | 29 | F | N | N | N | + | + | ++ | ++ | ++ | + | |||||||||
8 | 37 | F | N | 2 | 2 | N | N | N | + | ++ | ++ | ++ | ++ | ++ | Or | Y | ||||
9 | 40 | F | N | 2 | 0 | Pt | N | N | + | ++ | ++ | ++ | ++ | ++ | N | |||||
10 | 45 | F | N | 0 | 2 | N | N | N | + | ++ | ++ | ++ | ++ | ++ | Y | Y | ||||
11 | 47 | M | N | 0 | 3 | N | N | N | + | ++ | ++ | ++ | ++ | + | Or | Y | ||||
12 | 50 | M | N | 2 | 1 | N | AQ | Th↓ | ++ | ++ | ++ | ++ | ++ | + | Cp | Y | ||||
13 | 51 | F | 20 | A | S? | N | 3 | 4 | N | N | N | + | ++ | ++ | ++ | ++ | + | N | Y | |
14 | 51 | M | 30 | A | F | N | 0 | 1 | N | N | N | + | ++ | ++ | ++ | ++ | + | Y | ||
15 | 54 | F | 20 | A | K | N | 4 | 0 | Pt | N | N | + | ++ | ++ | ++ | ++ | ++ | N | ||
16 | 55 | M | 20 | A | K | N | 2 | 1 | Pt | N | N | + | ++ | ++ | ++ | ++ | 0 | Or | Y | |
17 | 60 | F | N | 4 | 2 | N | N | N | + | ++ | ++ | ++ | ++ | 0 | N | Y | ||||
18 | 63 | M | N | 2 | 2 | N | N | N | (+) | ++ | ++ | ++ | ++ | 0 | Y | |||||
19 | 63 | F | N | 3 | 3 | N | N | N | + | ++ | ++ | ++ | ++ | + | Y | |||||
20 | 66 | F | NP | NP | 4 | 5 | Pt | AH | N | + | ++ | ++ | ++ | ++ | 0 | Y | ||||
21 | 69 | F | N | 0 | 2 | N | N | N | + | ++ | ++ | ++ | ++ | 0 | N | Y | ||||
22 | 72 | F | NP | NP | 5 | 2.5 | Ti | N | Th↓ | + | ++ | ++ | ++ | 0 | N | |||||
23 | 74 | M | 50 | A | KA | NP | 1 | 5 | N | AH | Th↓ | (+) | ++ | ++ | ++ | + | 0 | Or | Y | Y |
24 | 82 | M | 70 | A | K | NP | 2 | 5 | N | N | Th↓ | – | ++ | ++ | ++ | ++ | 0 | B12 | ||
25 | 84 | F | 70 | A | K | NP | 0 | 1 | N | AH | N | – | ++ | ++ | + | + | + | Or | Y | |
26 | 90 | M | 60 | A | K | NP | 1 | 3 | Pu | AQ AH | N | (+) | ++ | ++ | + | + | 0 | Y | ||
Young | 34 | Mean | 1.00 | 1.00 | Mean | |||||||||||||||
1.29 | 1.30 | SD | ||||||||||||||||||
Old | 71 | Mean | 2.18 | 2.90 | Mean | |||||||||||||||
1.66 | 1.75 | SD | ||||||||||||||||||
All | 50 | Mean | 2.00 | 1.79 | Mean | |||||||||||||||
22.7 | SD | 1.53 | 1.70 | SD |
We found no mutilating symptoms, autoamputations, painless fracture, multiple infections or mental retardation.
Charcot joint: A, ankle; F, foot; K, knee; S, spine.
Reflexes: –, absent; (+), reduced; +, normal; ++, high.
Sensation: 0, absent; +, reduced; ++, normal.
A, arthropathy; AH, atrophy hand; AQ, atrophy quadriceps; B12, B12 deficiency; CN, clinical neuropathy; Cp, cerebral palsy; CTS, carpal tunnel syndrome; MNSI, Michigan Neuropathy Screening Instrument; N, normal or no; NP, polyneuropathy; Or, ortostatism; Pt, ptosis; Pu, different pupil size; Th, toe–heel test; Ti, tinnitus; Y, yes.