Case No(age in years) | Clinical symptoms of NP and/or CA | No of myelinated nerve fibres/ mm2×103 | Mean circular diameter (μm) | Ratio of myelinated nerve fibres <7/>7 μm |
10 (45) | No symptoms | 8.7 | 7.6 | 1.2 |
13 (51) | NP/CA | 6.4 | 7.4 | 0.8 |
17 (60) | No symptoms | 6.3 | 8.6 | 1.3 |
21 (69) | No symptoms | 6.3 | 7.5 | 1.3 |
23 (74) | NP/CA | 5.1 | 7.1 | 1.0 |
25 (84) | NP/CA | 5.8 | 7.1 | 1.2 |
Mean values | ||||
Patients (45–84) | 6.4 (1.2) | 7.5 (0.6) | 1.1 (0.2) | |
Controls (18–61) | 9.6 (1.5) | 5.8 (0.6) | 2.1 (0.5) | |
p Value (t test) | 0.001 | 0.0001 | 0.0001 | |
p Value (Mann–Whitney U test) | 0.002 | 0.001 | 0.002 |
Individual and mean (SD) values for the sural nerve in six patients with HSAN V and in 10 healthy controls.15
CA, Charcot arthropathy; HSAN, hereditary sensory and autonomic neuropathies; NP, neuropathy.