NP normal/CDR normal (n = 1451) Subgroup 1 | NP normal/CDR MCI (n = 751) Subgroup 2 | NP MCI/CDR normal (n = 381) Subgroup 3 | NP MCI/CDR MCI (n = 480) Subgroup 4 | ANOVA F | |
Episodic memory | |||||
CVLT long delay recall | 9.9 (2.8)a | 8.8 (2.9)b | 7.9 (3.2)c | 6.3 (2.9)d | 173.79*** |
R-O delayed recall | 17.3 (4.0)a | 16.9 (4.0)a | 13.2 (5.2)b | 11.9 (5.2)c | 234.65*** |
Attention/perceptual speed | |||||
Digit span forward | 6.3 (1.3)a | 6.1 (1.3)a | 5.9 (1.3)b | 5.8 (1.3)b | 14.83*** |
Trails A (s) | 39.5 (11.8)a | 42.6 (12.1)b | 50.0 (18.5)c | 54.8 (24.3)d | 113.06** |
Visuospatial construction | |||||
R-O copy (24 points) | 22.6 (1.7)a | 22.7 (1.6)a | 20.6(3.0)b | 20.6 (3.2)b | 176.00** |
Block design (24 points) | 13.2 (3.8)a | 12.1 (3.8)b | 9.7 (4.6)c | 8.7 (4.3)d | 168.91*** |
Language | |||||
30 point BNT | 27.4 (2.2)a | 27.0 (2.5)b | 25.6 (3.4)c | 24.5 (3.9)d | 134.11*** |
Category fluency | 17.1 (4.2)a | 16.3 (3.9)b | 14.2 (4.2)c | 13.0 (3.6)d | 133.49*** |
Executive functions | |||||
Trails B (s) | 95.0 (33.0)a | 111.1 (40.3)b | 127.9 (49.6)c | 148.7 (55.1)d | 192.70*** |
Stroop interference | 83.2 (19.9)a | 76.9 (19.5)b | 66.1 (23.1)c | 59.8 (22.0)d | 151.20*** |
Values are mean (SD).
Overall Fs reported for ANCOVAS with age, education, race and CESD score included as covariates. Means within a given row with different superscripts (a, b, c, d) are statistically different at p<0.05 by Student–Neuman–Keuls procedure.
***p<0.001.
BNT, Boston Naming Test; CDR, Clinical Dementia Rating; CESD, Center for Epidemiological Studies Depression Scale; CVLT, California Verbal Learning Test; MCI, mild cognitive impairment; NP, neuropsychological; R-O, Rey–Osterrieth.