Table 1 Clinical profiles of patients with Fisher syndrome overlapping Guillain–Barré syndrome (FS/GBS)
FS/GBSGBSFSTwo-tailed p value
TotalVentilatedUnventilatedFS/GBS vs GBSFS/GBS vs FSVentilated vs unventilated FS/GBS
No of patients451134100100
Sex (male/female)29/168/321/1355/4554/46NSNSNS
Age (years): median (range)46 (6 to 73)46 (19 to 68)45 (6 to 73)52 (4 to 92)43 (8 to 85)NSNSNS
Antecedent illness: n (%)
    Upper-respiratory infectious symptoms29 (64%)7 (64%)22 (65%)52 (52%)55 (55%)NSNSNS
    Diarrhoea7 (16%)0 (0%)7 (21%)38 (38%)24 (24%)0.01NSNS
Initial symptom: n (%)
    Diplopia20 (44%)5 (45%)15 (44%)1 (1%)65 (65%)<0.0010.03NS
    Titubation12 (27%)6 (55%)6 (18%)0 (0%)34 (34%)<0.001NS0.04
    Dysphagia2 (4%)0 (0%)2 (6%)2 (2%)0 (0%)NSNSNS
    Nasal voice2 (4%)0 (0%)2 (6%)0 (0%)0 (0%)NSNSNS
    Leg weakness0 (0%)0 (0%)0 (0%)41 (41%)0 (0%)<0.001NSNS
Neurological signs during illness: n (%)
    External ophthalmoplegia45 (100%)11 (100%)34 (100%)8 (8%)100 (100%)<0.001NSNS
    Internal ophthalmoplegia10 (22%)3 (27%)7 (21%)1 (1%)31 (31%)<0.001NSNS
    Facial weakness4 (9%)0 (0%)4 (12%)38 (38%)19 (19%)<0.001NSNS
    Oropharyngeal palsy19 (42%)5 (45%)14 (41%)33 (33%)10 (10%)NS<0.001NS
    Neck weakness27 (60%)9 (82%)18 (53%)51 (51%)13 (13%)NS<0.001NS
    Limb weakness
        Ascending tetraparesis31 (69%)4 (36%)27 (79%)94 (94%)0 (0%)<0.001<0.0010.02
        Descending tetraparesis14 (31%)7 (64%)7 (21%)6 (6%)0 (0%)<0.001<0.0010.02
    Ataxia45 (100%)11 (100%)34 (100%)4 (4%)100 (100%)<0.001NSNS
    Superficial sense impairment23 (51%)4 (36%)19 (56%)28 (28%)6 (6%)0.01<0.001NS
    Deep sense impairment18 (40%)5 (45%)13 (38%)18 (18%)12 (12%)0.009<0.001NS
Artificial ventilation: n (%)11 (24%)10 (10%)0 (0%)0.04<0.001
    Median days to artificial ventilation (range)2 (1 to 6)6 (1 to 25)0.03
Median days to admission (range)2 (0 to 13)2 (0 to 10)2 (0 to 13)3 (0 to 17)3 (0 to 18)NS0.040.008
  • NS, not significant (p>0.05)