Table 2 Antimuscarinics available in the UK
Generic nameTrade nameDose (mg)FrequencyReceptor subtype selectivityMolecule typeActive metaboliteElimination half-life of drug (h)
PropanthelinePro-Banthine15tdsNon-selectiveQuaternary amineNo<2
Tolterodine tartrateDetrusitol2bdNon-selectiveTertiary amineYes2.4
Tolterodine tartrateDetrusitol XL4odNon-selectiveTertiary amineYes8.4
Trospium chlorideRegurin20bdNon-selectiveQuaternary amineNo20
Oxybutynin chlorideDitropan2.5–5bd - qdsNon-selectiveTertiary amineYes2.3
Oxybutynin chloride XLLyrinel XL5–30odNon-selectiveTertiary amine (R and S isomers)Yes13.2
Propiverine hydrochlorideDetrunorm15od - qdsNon-selectiveEsterYes4.1
DarifenacinEmselex7.5–15odSelective muscarinic M3 receptor antagonistTertiary amineYes3.1
SolifenacinVesicare5–10odSelective muscarinic M2 and M3 receptor antagonistTertiary amineYes40–68
FesoterodineToviaz4–8odNon-selectiveTertiary amineYes7
  • bd, twice daily; od, once daily; qds, four times daily; tds, three times daily; XL, extended life.