Patient No 1 | Patient No 2 | Patient No 3 | Patient No 4 | Patient No 5 | Patient No 6 | Patient No 7 | Patient No 8 | Patient No 9 | Patient No 10 | Patient No 11 | Patient No 12 | % +ve | |
Perimysial pathology | 92 | ||||||||||||
Fragmentation | + | + | + | − | + | + | + | + | + | + | − | − | 75 |
Acid phosphatase + cells | + | + | + | + | + | + | + | − | + | + | − | + | 83 |
Alkaline phosphatase stain | + | + | + | + | − | + | + | − | + | − | − | − | 58 |
Inflammation | |||||||||||||
Mononuclear cell foci | 50 | ||||||||||||
Endomysial | − | − | − | + | − | + | − | − | + | − | − | − | 25 |
Perivascular | + | − | + | − | − | − | − | − | − | − | − | + | 25 |
Muscle fibre pathology | |||||||||||||
Perifascicular | 58 | ||||||||||||
Atrophy | + | − | − | + | + | + | − | − | + | + | − | + | 58 |
Necrosis and regeneration | + | − | − | − | − | + | − | − | + | + | − | − | 33 |
COX stain reduced | − | − | − | − | − | + | − | − | + | − | − | − | 17 |
MHC-I staining | + | − | + | + | + | + | + | + | + | + | − | + | 83 |
Small vessel pathology | 17 | ||||||||||||
Alkaline phosphatase stain | − | − | − | − | − | − | − | − | − | − | − | − | 0 |
C5b-9 deposition | − | − | − | − | + | − | + | − | − | − | − | − | 17 |
Capillary number reduced | − | − | − | − | − | − | − | − | + | − | − | − | 8 |
Muscle pathology findings: +, present; −, negative/absent; % +ve, per cent positive.
Alkaline phosphatase stain = increased number of endomysial capillaries with positive staining.
COX, cytochrome oxidase; MHC-I, major histocompatibility complex.