Table 2

Left: FA values (×1000) of different ROIs in epilepsy patients and healthy controls (n=67). Right: AI of temporal FA values in CPE patients and the deviation from the mean AI of the healthy controls

FA values (×1000) of Control groupFA values (×1000) of CPE patientsp ValuesAsymmetry indices (100×(FA left temporal lobe–FA right temporal lobe)/(FA left temporal lobe+FA right temporal lobe))Difference to AI of healthy controls
Mean±SDMean±SD
Whole brain357.615.6331.424.7<0.001*With left-hemispheric focus (n=4)
Corpus callosum414.337.0351.244.9<0.001*Patient No 2−7.0−7.3
Genu410.146.9371.824.90.008*Patient No 6−9.7−10.0
Splenium457.040.9413.364.40.013*Patient No 7−7.6−7.9
Capsula interna413.917.0392.124.20.010*Patient No 8−2.7−3.0
Cerebellum311.821.8299.732.40.218With right hemispheric focus (n=5)
Corona radiata354.115.8319.831.6<0.001*Patient No 15.14.8
Corticospinal tract389.615.9344.929.10.001*Patient No 91.51.2
Brainstem408.317.4384.815.90.003*Patient No 104.34.0
Frontal lobe336.219.4298.832.1<0.001*Patient No 113.02.7
Temporal lobes367.116.1334.731.4<0.001*Patient No 114.94.6
Left temporal lobe368.217.8329.729.4<0.001*Non-localisation/bilateral focus (n=3)
Right temporal lobe366.016.2340.418.10.001*Patient No 3−0.4−0.7
Occipital lobe336.026.2332.840.20.232Patient No 4−2.0−2.3
Parietal lobes354.517.7348.419.60.163Patient No 5−1.5−1.8
Thalamus438.636.8428.231.50.755
  • Left: Significant FA reductions in CPE patients were widespread, encompassing diffuse areas of the brain. Right: The lateralization of the temporal FA changes concurred with the hemisphere comprising the putative seizure focus in all patients.

  • * Significant FA reduction, p<0.05 lower than healthy controls.

  • AI, asymmetry index; CPE, cryptogenic partial epilepsy; FA, fractional anisotropy; ROIs, regions of interest.