Hazard ratios for time from MS onset and age to reach EDSS 6 based on Cox regression analysis after correction for age at onset
| Comparison* | Hazard ratio (95% CI) | p Value |
| Time from onset of MS to reach EDSS 6 | ||
| Group 3 versus 1 | 0.61 (0.37 to 0.99) | 0.049 |
| Groups (2, 3 and 4) versus 1 | 0.66 (0.47 to 0.95) | 0.023 |
| Age at EDSS 6 | ||
| Group 3 versus 1 | 0.57 (0.35 to 0.94) | 0.027 |
| Groups (2, 3 and 4) versus 1 | 0.68 (0.48 to 0.97) | 0.032 |
*Patient groups: 1, no children; 2, children only before onset of MS; 3, children only after onset of MS; 4, children before and after onset of MS.