Table 2

Multiple regression model to identify determinants of increased blood–brain barrier permeability in normal-appearing white matter and cerebrospinal fluid

	Normal-appearing white matter	Cerebrospinal fluid
R²	0.494	0.603
ANOVA
F	3.144	4.897
p Value	0.009	<0.0005

Variables	β	p Value	β	p Value
Age	−0.138	0.492	−0.293	0.105
Gender	0.04	0.79	−0.185	0.166
Weight	−0.551	0.007	−0.085	0.619
Brain volume	−0.04	0.821	0.18	0.257
Leucoaraiosis grade	0.364	0.027	0.542	0.001
Area under curves in ICA	−0.134	0.459	0.233	0.152
Hypertension	0.232	0.164	−0.001	0.995
Diabetes	−0.017	0.913	−0.124	0.369
Current smoking	0.112	0.5	0.204	0.172