Table 5

Comparison of patients with vegetative state secondary to hypoxic brain injury to those caused by traumatic brain injury and controls

			Controls	Traumatic brain injury	Hypoxic brain injury
			Median (IQR)	Median (IQR)	Median (IQR)
Whole-brain central white matter (WBCWM)		FA	0.42 (0.41 to 0.43)	0.25 (0.20 to 0.32)^*	0.27 (0.22 to 0.28)^*
		ADC	0.66 (0.65 to 0.67)	1.13 (0.90 to 1.28)^*	1.21 (1.02 to 1.34)^*
		Axial	0.97 (0.95 to 0.98)	1.33 (1.12 to 1.45)^*	1.28 (1.51 to 1.88)
		Radial	0.50 (0.49 to 0.52)	1.03 (0.74 to 1.12)^*	1.06 (0.89 to 1.44)^*
		Tracts	42367 (3856 to 5109)	1225 (782 to 2042)^*	748 (173 to 3135)^*
Whole-brain grey matter		FA	1.73 (1.68 to 1.81)	0.17 (0.13 to 0.19)	0.17 (0.15 to 0.20)
		ADC	0.79 (0.77 to 0.81)	0.91 (0.76 to 0.95)	1.13 (0.92 to 1.35)^*
		Axial	0.92 (0.90 to 0.94)	1.05 (0.86 to 1.16)	1.11 (1.29 to 1.57)^*
		Radial	0.73 (0.71 to 0.75)	0.84 (0.71 to 0.87)	1.06 (0.82 to 1.06)^*
		Tracts	4517 (4127 to 5611)	1112 (663 to 2001)	720 (158 to 3019)^*
Cortical contusions	Anterior	FA	0.57 (0.52 to 0.59)	0.33 (0.21 to 0.48)^*	0.45 (0.28 to 0.51)^*
		ADC	0.69 (0.67 to 0.72)	0.99 (0.85 to 1.19)^*	0.86 (0.75 to 1.28)^*
		Axial	1.17 (1.14 to 1.24)	1.37 (1.19 to 1.57)^*	1.34 (1.19 to 1.62)
		Radial	0.44 (0.41 to 0.48)	0.88 (0.59 to 1.06)^*	0.62 (0.53 to 1.62)^*
		Tracts	114 (103 to 138)	34 (14 to 200)^*	12 (4 to 85)^*
	Posterior	FA	0.69 (0.67 to 0.72)	0.37 (0.30 to 0.46)^*	0.28 (0.23 to 0.39)^*
		ADC	0.68 (0.65 to 0.71)	0.92 (0.88 to 1.07)^*	0.99 (0.98 to 1.55)^*
		Axial	1.32 (1.28 to 1.38)	1.31 (1.22 to 1.41)	1.53 (1.24 to 1.94)
		Radial	0.36 (0.32 to 0.39)	0.74 (0.68 to 0.78)^*	0.87 (0.78 to 1.36)^*
		Tracts	319 (224 to 443)	22 (0 to 56)^*	17 (3 to 34)^*
Thalamus		FA	0.34 (0.33 to 0.36)	0.32 (0.30 to 0.35)	0.42 (0.40 to 0.47)^* ^†
		ADC	0.66 (0.63 to 0.68)	0.85 (0.83 to 0.88)^*	0.79 (0.67 to 0.92)^*
		Axial	0.90 (0.88 to 0.93)	1.12 (1.07 to 1.17)^*	1.01 (0.95 to 1.28)^*
		Radial	0.54 (0.52 to 0.56)	0.72 (0.67 to 0.74)^*	0.58 (0.51 to 0.73)
		Tracts	728 (611 to 825)	212 (137 to 318)^*	86 (28 to 497)^*
Midbrain	Ventral	FA	0.56 (0.54 to 0.59)	0.39 (0.36 to 0.48)^*	0.59 (0.56 to 0.60) ^†
		ADC	0.61 (0.57 to 0.64)	0.69 (0.63 to 0.80)^*	0.67 (0.58 to 0.70)
		Axial	1.02 (0.98 to 1.09)	0.97 (0.89 to 1.25)	1.09 (0.95 to 1.16)
		Radial	0.40 (0.37 to 0.42)	0.55 (0.50 to 0.63)^*	0.43 (0.39 to 0.48) ^†
		Tracts	618 (563 to 753)	74 (10 to 499)^*	133 (50 to 260)^* ^†
	Dorsal	FA	0.47 (0.44 to 0.50)	0.31 (0.25 to 0.34)^*	0.51 (0.46 to 0.60) ^†
		ADC	0.66 (0.62 to 0.69)	0.80 (0.75 to 0.83)^*	0.64 (0.60 to 0.72) ^†
		Axial	1.01 (0.98 to 1.04)	1.04 (1.00 to 1.20)	1.03 (0.95 to 1.15)
		Radial	0.49 (0.45 to 0.51)	0.69 (0.60 to 0.73)^*	0.47 (0.42 to 0.50) ^†
		Tracts	233 (213 to 300)	49 (17 to 141)^*	62 (47 to 249)^* ^†
Pons		FA	0.52 (0.49 to 0.53)	0.38 (0.37 to 0.41)^*	0.52 (0.47 to 0.54) ^†
		ADC	0.58 (0.56 to 0.61)	0.71 (0.67 to 0.76)^*	0.61 (0.55 to 0.67) ^†
		Axial	0.93 (0.89 to 0.97)	1.01 (0.94 to 1.08)^*	0.97 (0.86 to 1.06)
		Radial	0.41 (0.39 to 0.43)	0.56 (0.54 to 0.61)^*	0.43 (0.39 to 0.48) ^†
		Tracts	347 (263 to 407)	60 (30 to 238)^*	87 (12 to 157)^* ^†

The median (IQR) values for the traumatic brain injury and controls are listed in tables 3, 4. Significant comparisons (p<0.017) are shown.
↵* Significant differences of each patient group from the controls.
↵† Significant differences between the two patient groups.
ADC, apparent diffusion coefficient; FA, fractional anisotropy.