Correlation between conventional MRI parameters at baseline, and aPBVC and aPVVC for both time intervals
| aPBVC 0–2 | aPBVC 2–5.5 | aPVVC0–2 | aPVVC2–5.5 | ||
| T2LL (cm3) | ρ | −0.39 | −0.02 | 0.37 | 0.29 |
| p Value | ** | NS | ** | * | |
| T1LL (cm3) | ρ | −0.19 | −0.04 | 0.22 | 0.25 |
| p Value | NS | NS | NS | NS | |
| GdLL (cm3) | ρ | −0.28 | −0.02 | 0.39 | 0.28 |
| p Value | * | ns | ** | * | |
| T2supraLL (cm3) | ρ | −0.43 | 0.02 | 0.38 | 0.27 |
| p Value | ** | ns | ** | * | |
| T2infraLL (cm3) | ρ | −0.05 | −0.19 | 0.12 | 0.25 |
| p-value | ns | ns | ns | ns | |
| ΔT1LL 0–2 years | ρ | −0.29 | −0.25 | 0.16 | 0.34 |
| p-value | * | 0.064 | ns | * | |
| ΔT2LL 0–2 years | ρ | −0.27 | −0.13 | 0.22 | 0.27 |
| p-value | * | ns | ns | 0.052 |
Results are presented as Spearman's rank correlation coefficients (ρ). Correlation coefficients between aPBVC and (change of) lesion loads are negative, indicating that a higher (increase of) lesion load was accompanied by faster brain volume loss. For aPVVC, correlation coefficients with (change of) lesion loads are positive, indicating that a higher (increase of) lesion load was accompanied by faster ventricular volume increase.
*p<0.05; **p<0.01.
0–2, time interval between baseline and 2 years of follow-up; 2–5.5, time interval between 2 and 5.5 years of follow-up; Δ, difference between two time points; aPBVC, annual percentage brain volume change; aPVVC, annual percentage ventricular volume change; GdLL, lesion load of enhancing lesions; T1LL, T1 lesion load; T2LL, T2 lesion load.