Table 3

Regions showing significant grey matter atrophy in clinically isolated syndrome patients (n=62) compared with controls (n=37)(p<0.005, FWE corrected)

Regions	Side	Brodmann areas	Talairach coordinates	T	No of voxels
Caudate	Right	NA	−16 20 5	10.6	4848
Caudate	Left	NA	14 18 3	9.73
Lenticular nucleus	Right	NA	−26 6 5	6.6
Lenticular nucleus	Left	NA	26 4 3	6.1
Thalamus	Right	NA	−14 –31 11	7.7
Thalamus	Left	NA	12 –19 16	7.3
Amygdala	Right	NA	24 -6 -13	10.12
Insula	Right	NA	−36 2 7	5.6
	Left	NA	42 10 7	5.7
Cerebellum	Right	NA	−40 −78 −15	7	1620
Cerebellum	Left	NA	22 −88 −16	6.7	1620
Orbito-frontal cortex	Left	BA 47	48 38 −10	7.3	423
		BA 47	28 9 −17	7.3
		BA 11	25 50 −16	5.7
			18 38 −22	6.4
	Right	BA47	−26 9 −17	7.7	297
	Right	BA 11	−32 44 −12	7.4
			−12 40 −20	7
Hippocampus	Right	NA	−28 −18 −11	7.5	287
	Right	NA	−32 −29 −5	7	287
	Left	NA	32 −30 −5	5.3	86
Posterior cingulate cortex		BA 31	0 −34 27	7.1	71
Inferior temporal cortex	Right	BA 20	−36 −6 −38	7.5	38
	Right	BA 20	−57 −21 −24	6.2	38
	Left	BA 37	57 −47 −9	5.9	22
	Left	BA 20	38 −4 −40	5.4	22