Table 2

Conventional and diffusion tensor MRI findings in the six groups of subjects studied

Paediatric healthy volunteersAdult healthy volunteersPaediatric CIS patientsPaediatric RRMS patientsAdult CIS patientsAdult RRMS patients
T2 LV (SD) (ml)0012.6 (16.3)9.5 (10.9)4.8 (0.54)11.1 (12.6)
Infratentorial LV (SD) (ml)000.6 (1.1)0.7 (1.4)0.3 (0.7)0.5 (0.8)
ICV (SD) (ml)1361 (149)1402 (90)1435 (148)1380 (92)1412 (109)1398 (106)
T2 LV/ICV % (SD)1.0 (1.0)0.6 (0.9)0.3 (0.6)0.7 (1.0)
Average lesion FA (SD)0.26 (0.03)0.26 (0.03)0.28 (0.04)0.25 (0.03)
Average lesion MD (SD)1.06 (0.01)1.03 (0.08)1.07 (0.01)1.18 (0.01)
NAWM average FA (SD)0.30 (0.01)0.30 (0.01)0.27 (0.02)0.26 (0.02)0.28 (0.02)0.27 (0.03)
NAWM average MD (SD)0.83 (0.02)0.81 (0.03)0.84 (0.02)0.86 (0.04)0.82 (0.03)0.86 (0.07)
GM average MD (SD)0.98 (0.02)0.98 (0.04)0.98 (0.04)1.00 (0.05)0.99 (0.03)1.06 (0.08)
  • CIS, clinical isolated syndrome; FA, fractional anisotropy; GM, grey matter; ICV, intracranial volume; LV, lesion volume; MD, mean diffusivity; NAWM, normal-appearing white matter; RRMS, relapsing remitting multiple sclerosis.

  • The mean diffusivity is expressed in units of mm2 s−1×10−3, and FA is a dimensionless index. For the statistical analysis, see the text.