CMT1A n=49 | MMN n=15 | ||
Grip strength | Mean %±SD of norm* | 65±25.4 | 36 (24.8; 50.6) |
Range | 9.8–111.5 | 2.7–90.7 | |
Two-point pinch strength† | Mean %±SD of norm* | 49±27.7 | 0 (0; 51.8) |
Range | 0–98.1 | 0–79.0 | |
Tripod pinch strength† | Mean %±SD of norm* | 47±28.5 | 0 (0; 42.1) |
Range | 0–102.1 | 0–96.3 | |
Lateral pinch strength | Mean %±SD of norm* | 51±22.4 | 30 (20.2; 66.7) |
Range | 5.8–93.3 | 2.6–87.7 |
Published reference values of healthy subjects, stratified by age, gender and hand dominance, were used to understand the impact of Charcot–Marie–Tooth disease type 1A (CMT1A) on hand strength. The dominant hand was taken for comparison.
↵* Median % and the 25; 75 percentile scores are given for multifocal motor neuropathy (MMN) patients, as data were skewed.
↵† Five CMT1A and nine MMN patients were not able to perform a two-point pinch, and six CMT1A and nine MMN patients were not able to perform a tripod pinch, which resulted in a score of 0 N.