Table 1

Clinical and MRI baseline observations, and last review EDSS scores, in the cohort followed-up over 6 years from their index clinical event

Subtype
CDMSRDMSECISSCIS
Further clinical eventsYesNoNoNo
New MRI lesionsNot requiredYesYesNo
Gender (F/M)42/126/108/515/7
Age at first event (years) (mean (SD))33.0 (7.7)36.6 (6.3)34.3 (7.5)32.3 (7.5)
T2 lesion volume (ml) (median (range))1.3 (0.0–25.1)1.2 (0.3–9.6)0.1 (0.0–0.5)0.0 (0.0–0.8)
T2 lesion number (median (range))12 (0–142)13.5 (3–57)1 (0–6)0 (0–5)
Gd enhancing lesion number (median (range))0 (0–21)0 (0–13)0 (0–3)0 (0–0)
First review EDSS (median (range))1.0 (0.0–6.0)1.0 (0.0–3.0)1.0 (0.0–3.0)1.0 (0.0–4.0)
6 year EDSS (median (range))2.0 (0.0–7.5)1.0 (0.0–2.0)1.0 (0.0–2.0)1.0 (0.0–2.5)
  • N=105, except for baseline EDSS, where N=103 (N=53 for CDMS and N=21 for SCIS) and 6-year EDSS scores, where N=104 (N=15 for RDMS).

  • CDMS, clinically definite multiple sclerosis; ECIS, evolving clinically isolated syndrome; EDSS, expanded disability status scale; RDMS, radiologically defined multiple sclerosis; SCIS, stable clinically isolated syndrome.