Demographic characteristics of the cohort
| Characteristic | Value |
| n | 193 |
| Women:men (% women) | 152:41 (79) |
| MS type (n (%)) | |
| RR-MS | 170 (88.1) |
| SP-MS | 23 (11.9) |
| Race (n (%)) | |
| Caucasian | 177 (91.7) |
| African–American | 11 (5.7) |
| Hispanic or multiracial | 5 (2.6) |
| Age (years) | 46.1±8.4 |
| Age of onset (years) | 32.3±10.1 |
| Disease duration (years) | 13.8±8.4 |
| Treatment duration (years) | 4.0±3.4 |
| EDSS | 2.5 (1.5–3.5) |
| MSSS | 3.5±2.3 |
| MRI characteristic | Value |
| T2-LV (cm3) | 14.5 (7.9–29.3) |
| T1-LV (cm3) | 1.8 (0.49–7.5) |
| BPF | 0.875±0.022 |
Data are mean±SD except for EDSS, T2-LV and T1-LV (median(25th-percentile–75th-percentile).
BPF, brain parenchymal fraction; EDSS, Expanded Disability Status Scale; LV, lesion volume; MSSS, Multiple Sclerosis Severity Scale; RR-MS, relapsing–remitting multiple sclerosis; SP-MS, secondary progressive multiple sclerosis.