Table 1

Clinical heterogeneity in affected members of family VSM-20

PatientSexOnset (years)Duration (years)First SymptomsClinical syndrome(s) present
Frontotemporal dementiaAmyotrophic lateral sclerosisParkinsonismOther
I-2F573Apathy, delusions++Delusions
II-3M352.5Hand weakness+
II-4M507Poor judgement, apathy+
II-7F469Disoriented, bradyphrenia+++Pseudobulbar affect
II-8M4710Poor judgement, dysexecutive+
III-2M49AliveApathy, depression++
III-3M49AliveApathy, poor judgement+
III-7F393Acalculia, Apraxia+++Supranuclear gaze palsy
III-9F40AliveLeg weakness+
III-15M41AliveApathy dysexecutive++