Clinical heterogeneity in affected members of family VSM-20
Patient | Sex | Onset (years) | Duration (years) | First Symptoms | Clinical syndrome(s) present | |||
Frontotemporal dementia | Amyotrophic lateral sclerosis | Parkinsonism | Other | |||||
I-2 | F | 57 | 3 | Apathy, delusions | + | + | Delusions | |
II-3 | M | 35 | 2.5 | Hand weakness | + | |||
II-4 | M | 50 | 7 | Poor judgement, apathy | + | |||
II-7 | F | 46 | 9 | Disoriented, bradyphrenia | + | + | + | Pseudobulbar affect |
II-8 | M | 47 | 10 | Poor judgement, dysexecutive | + | |||
III-2 | M | 49 | Alive | Apathy, depression | + | + | ||
III-3 | M | 49 | Alive | Apathy, poor judgement | + | |||
III-7 | F | 39 | 3 | Acalculia, Apraxia | + | + | + | Supranuclear gaze palsy |
III-9 | F | 40 | Alive | Leg weakness | + | |||
III-15 | M | 41 | Alive | Apathy dysexecutive | + | + |