Table 2

Patterns of brain atrophy in affected VSM-20 family members

VSM-20 familySporadic behavioural-variant frontotemporal dementiaNormalOverall ANOVA
n51013
Age49.3±6.058.7±6.054.8±3.7F(2,25)=5.93
Gender (male/female)4/18/210/3
Disease duration3.00±1.415.40±2.63NANS
Clinical dementia rating total0.7±0.4**0.8±0.3**0.0±0.0F(2,23)=30.8
Clinical dementia rating-sum of boxes3.8±2.5**3.8±2.1**0.0±0.0F(2,25)=19.5
Mean volume±SD (×103 mm3)
 Cortex387±21**404±31**472±40F(2,24)=16.4
 Cerebellum131±10143±13*132±14F(2,24)=3.07
 Brainstem19.5±1.122.5±2.121.6±3.1F(2,24)=2.52
 Cerebrospinal fluid2.18±0.59**1.99±0.46 **1.27±0.23F(2,24)=20.0
 Cerebral white matter376±24*429±69465±62F(2,24)=4.46
 Cerebral grey matter395±30**433±30*484±44F(2,24)=12.4
 Left frontal lobe71.3±7.0**81.1±11.7*96.2±14.6F(2,24)=7.98
 Right frontal lobe71.8±7.3**74.1±12.8**96.0±14.2F(2,24)=10.5
 Left parietal lobe51.9±3.8*57.8±5.159.2±6.0F(2,24)=3.29
 Right parietal lobe51.7±3.7*56.6±5.461.1±7.9F(2,24)=3.98
 Left temporal lobe48.0±2.6*45.1±7.5*54.4±6.4F(2,24)=5.71
 Right temporal lobe47.1±3.9*37.9±8.2**52.8±6.0F(2,24)=11.6
 Left occipital lobe23.0±2.325.4±1.825.5±3.0NS
 Right occipital lobe22.0±3.3*25.7±3.826.7±2.7F(2,24)=2.98
Mean grey-matter volume±SD (×103 mm3)
 Left temporal pole2.01±0.49*1.49±0.70**2.42±0.31F(2,24) =7.67
 Right temporal pole2.09±0.491.19±0.71**2.36±0.37F(2,24) =10.3
 Left entorhinal cortex1.75±0.231.12±0.62**2.03±0.32F(2,24) =9.44
 Right entorhinal cortex1.85±0.211.07±0.56**1.85±0.30F(2,24) =7.68
 Left hippocampus3.28±0.11*2.93±0.92**4.06±0.43F(2,24) =8.83
 Right hippocampus3.35±0.20**2.73±0.83**4.30±0.56F(2,24) =16.2
 Left amygdala1.51±0.111.27±0.41**1.72±0.22F(2,24) =5.50
 Right amygdala1.58±0.221.13±0.47**1.78±0.30F(2,24) =7.83
 Left thalamus5.93±0.406.91±0.996.72±1.00NS
 Right thalamus5.93±0.40*6.66±0.676.92±0.95F(2,24)=3.37
 Left nucleus accumbens0.50±0.100.29±0.13 **0.54±0.06F(2,24)=14.0
 Right nucleus accumbens0.48±0.11*0.28±0.11 **0.60±0.09F(2,24)=21.2
 Left caudate3.16±0.453.09±0.843.44±0.34NS
 Right caudate3.17±0.262.52±0.92 **3.51±0.34F(2,24)=7.73
 Left putamen4.62±0.594.23±0.94**5.36±0.42F(2,24)=7.35
 Right putamen4.54±0.763.27±0.82 **5.04±0.43F(2,24)=16.7
  • Demographic values (ANOVA followed by post-hoc Tukey test); disease duration (independent-samples t test); volume comparisons (ANOVA, controlling for age).

  • * p<0.05 vs normal.

  • ** p<0.005 vs normal.

  • p<0.05 vs VSM-20 family.