Profile of aquaporin-4 antibody-positive patients in relapsing-remitting clinical course without optic neuritis or myelitis
| Case | Age at onset/gender | Lesion of first attack | Lesions involved in whole clinical course | No of relapses | Disease duration (year) | Complicated systemic diseases | Autoantibody | MRI cerebral lesion | |||
| No of lesions | Ovoid lesion | subcallosal lesion | |||||||||
| 1 | 51F | Cbr | Cbr, BS | 3 | 5 | (−) | ANA, SS | (+) | 4∼8 | (+) | (−) |
| 2 | 37M | Cbr | Cbr | 2 | 4 | (−) | (–) | (+) | ∼3 | (−) | (−) |
| 3 | 35F | Cbr | Cbr, BS | 2 | 2 | Hyper-thyroidism | ANA, SS | (−) | |||
| 4 | 21M | Cbr, BS | Cbr, BS | 3 | 1 | Hashimoto's chronic thyroiditis | ANA | (+) | 4∼8 | (+) | (+) |
| 5 | 19F | BS | BS, cerebellum* | 3 | 2 | (−) | ANA, SS | (−) | |||
| 6 | 40F | BS | Cbr | 2 | 2 | (−) | ANA, SS | (−) | |||
| 7 | 23F | BS | Cbr, BS | 4 | 4 | (−) | ANA | (+) | NA | NA | NA |
↵* Lesion detected on MRI alone.
ANA, antinuclear antibody; AQP4-ab, aquaporin 4 antibody; BS, brainstem; Cbr, cerebrum; F, female; M, male; NA, data not available; SS, SS-A/Ro antibody and/or SS-B/La antibody.