Comparison of prospective population based studies on amyotrophic lateral sclerosis epidemiology
| Country | Years | Patients (n) | Mean age at diagnosis | Incidence rate per 100 000 person-years | ||||
| M | F | 45–74 years | Peak incidence | >85 years | ||||
| Rate (95% CI)‡ | Age class | Rate (95% CI) | Rate (95% CI) | |||||
| USA (WA)12 | 1990–1995 | 235 | 57.3 | 64.5 | 5.6 (3.7 to 7.4) | 65–74 | 8.7 (6.6 to 10.7) | 6.1 (4.1 to 8.2)¶ |
| Ireland13 | 1995–1997 | 231 | 64.2 | 67.8 | 6.3 (4.6 to 7.9) | 70–74 | 10.9 (7.4 to 14.5) | 4.8 (0.6 to 9.0) |
| Scotland14 | 1989–1998 | 1226 | 65.1 | 68.1 | 5.5 (5.0 to 6.0) | 75–79 | 11.3 (9.6 to 13.3) | 2.3 (0.7 to 5.5)** |
| Italy, Puglia15 | 1998–1999 | 130 | 65.4 | 64.2 | 4.1 (2.6 to 5.7) | 65–74 | 7.7 (5.7 to 9.7) | 0.0 |
| Italy, Lombardy16 | 1998–2002 | 517 | N/A | N/A | 4.2 (3.4 to 5.1) | 65–74 | 6.8 (5.9 to 7.9) | 4.7 (3.9 to 5.9)¶ |
| Uruguay17 | 2002–2003 | 89 | 57.5 | 60.5 | 3.6 (2.7 to 4.5) | N/A | N/A | N/A |
| Italy, Piemonte and Valle d'Aosta18 | 1995–2004 | 1260 | 65.2 | 66.2 | 5.3 (5.0 to 5.6) | 70–74 | 10.4 (N/A) | 1.2 (N/A)** |
| Ireland19 | 2004–2005 | 109 | 64.6 | 66.1 | 5.7 (4.5 to 7.0) | 65–69 | 11.6 (7.4 to 17.3) | 0.0 |
| South East England20 | 2002–2006 | 138 | 60.7† | 64.6† | 2.3 (1.8 to 2.7) | 60–64 | 3.4 (2.1 to 4.7) | 1.2 (0.0 to 2.3) |
| France, Limousin21 | 1997–2007 | 201 | 68.1 | 67.8 | 4.2 (3.4 to 4.9)§ | 75–85 | 8.7 (N/A) | 1.6 (N/A) |
| The Netherlands* | 2006–2009 | 1217 | 63.0 | 65.2 | 4.4 (4.1 to 4.7) | 70–74 | 8.5 (7.3 to 9.6) | 1.5 (0.8 to 2.2) |
| The Netherlands (capture–recapture)* | 2006–2009 | 1495 | N/A | N/A | 5.3 (5.0 to 5.6) | 70–74 | 10.3 (9.0 to 11.6) | 2.8 (1.8 to 3.8) |
*Present study. †Median age at diagnosis. ‡Standardised to 1990 US population. §Standardised to 2000 US population. ¶Age class >75 years. **Age class >90 years. N/A, not applicable.