RRs of death associated with nutritional variables measured at diagnosis in univariate and multivariate analysis
| Nutritional variables at diagnosis* | Univariate analysis | Multivariate analysis | ||||
| Crude hazard ratio | 95% CI | p Value | Adjusted hazard ratio† | 95% CI | p Value | |
| Weight variation from usual weight (for 5% decrease) | 1.28 | 1.06 to 1.54 | 0.009 | 1.31 | 1.08 to 1.60 | 0.006 |
| BMI variation from usual BMI (for one unit decrease) | 1.20 | 1.06 to 1.36 | 0.005 | 1.23 | 1.07 to 1.41 | 0.003 |
| Rate of weight loss from usual weight (%/month) | 1.09 | 1.04 to 1.14 | 0.0002 | 1.07 | 1.02 to 1.12 | 0.003 |
| Rate of BMI loss from usual BMI (unit/month) | 1.35 | 1.16 to 1.58 | 0.0001 | 1.28 | 1.09 to 1.50 | 0.003 |
| Malnutrition at diagnosis versus other BMI categories | 1.67 | 0.79 to 3.50 | 0.18 | 1.32 | 0.62 to 2.80 | 0.47 |
| Mid-arm muscle circumference (cm, for one unit increase) | 0.96 | 0.90 to 1.03 | 0.23 | 0.95 | 0.89 to 1.01 | 0.12 |
| Triceps skinfold thickness (cm, for one unit increase) | 0.99 | 0.96 to 1.03 | 0.81 | 1.00 | 0.96 to 1.03 | 0.78 |
| Phase angle (°, for one unit decrease) | 1.29 | 1.02 to 1.63 | 0.03 | 1.15 | 0.87 to 1.52 | 0.33 |
| Extracellular fluid/intracellular fluid volume (for 0.2 unit increase) | 1.40 | 0.98 to 2.00 | 0.06 | 1.34 | 0.92 to 1.97 | 0.12 |
| Lean mass (kg, for 2.5 unit increase) | 0.97 | 0.92 to 1.03 | 0.33 | 1.00 | 0.94 to 1.07 | 0.90 |
| Fat mass (kg, for 2.5 unit increase) | 0.99 | 0.92 to 1.06 | 0.81 | 0.96 | 0.89 to 1.03 | 0.21 |
Significant p values appear in bold.
↵* Survival analyses were performed separately for each nutritional variable.
↵† Adjustment on age, gender, bulbar form at onset, amyotrophic lateral sclerosis Functional Rating Scale at diagnosis, manual muscular testing at diagnosis, forced vital capacity at diagnosis ≥80% versus <80%, Airlie House criteria at diagnosis definite, probable or probable laboratory-supported versus possible and diagnostic delay.