Table 2

RRs of death associated with nutritional variables measured at diagnosis in univariate and multivariate analysis

Nutritional variables at diagnosis*Univariate analysisMultivariate analysis
Crude hazard ratio95% CIp ValueAdjusted hazard ratio95% CIp Value
Weight variation from usual weight (for 5% decrease)1.281.06 to 1.540.0091.311.08 to 1.600.006
BMI variation from usual BMI (for one unit decrease)1.201.06 to 1.360.0051.231.07 to 1.410.003
Rate of weight loss from usual weight (%/month)1.091.04 to 1.140.00021.071.02 to 1.120.003
Rate of BMI loss from usual BMI (unit/month)1.351.16 to 1.580.00011.281.09 to 1.500.003
Malnutrition at diagnosis versus other BMI categories1.670.79 to 3.500.181.320.62 to 2.800.47
Mid-arm muscle circumference (cm, for one unit increase)0.960.90 to to 1.010.12
Triceps skinfold thickness (cm, for one unit increase)0.990.96 to 1.030.811.000.96 to 1.030.78
Phase angle (°, for one unit decrease)1.291.02 to 1.630.031.150.87 to 1.520.33
Extracellular fluid/intracellular fluid volume (for 0.2 unit increase)1.400.98 to to 1.970.12
Lean mass (kg, for 2.5 unit increase)0.970.92 to 1.030.331.000.94 to 1.070.90
Fat mass (kg, for 2.5 unit increase)0.990.92 to 1.060.810.960.89 to 1.030.21
  • Significant p values appear in bold.

  • * Survival analyses were performed separately for each nutritional variable.

  • Adjustment on age, gender, bulbar form at onset, amyotrophic lateral sclerosis Functional Rating Scale at diagnosis, manual muscular testing at diagnosis, forced vital capacity at diagnosis ≥80% versus <80%, Airlie House criteria at diagnosis definite, probable or probable laboratory-supported versus possible and diagnostic delay.