Table 1

Neuropsychological, behavioural and motor assessment according to CSF pattern

VariableCBS (n=30)CBSCBS with SPECT study available
nAD-like (n=24)AD-like (n=6)p ValuenAD-like (n=18)AD-like (n=5)p Value
MMSE23.6±6.1 (36.6)24.0±6.2 (29.2)21.3±5.8 (66.6)0.32425.1±3.6 (27.7)23.0±4.6 (60%)0.289
Short Story6.9±4.3 (66.6)7.8±4.3 (58.3)3.5±2.4 (100)0.0148.0±4.0 (55.5)3.8±2.6 (100)0.040
Raven C Matrices17.2±8.0 (43.3)18.3±7.6 (41.6)12.5±8.5 (50.0)0.10918.5±6.3 (38.8)15.0±6.5 (40.0)0.284
Rey Figure, copy18.5±11.8 (72.4)20.5±11.2 (69.5)10.9±12.3 (83.3)0.07821.0±9.4 (72.2)12.8±12.7 (80.0)0.126
Rey Figure, recall6.7±5.7 (65.5)7.1±5.6 (65.2)4.9±6.3 (66.6)0.4037.1±5.0 (66.6)5.9±6.5 (60.0)0.644
Phonological fluency16.7±10.0 (50.0)16.6±10.3 (50.0)17.1±10.0 (50.0)0.91616.3±8.3 (50.0)20.2±7.6 (40.0)0.369
Semantic fluency26.5±10.5 (50.0)27.1±10.5 (45.8)24±11.4 (66.6)0.52726.7±8.4 (50.0)26.6±10.6 (60.0)0.979
Digit Span4.6±1.5 (13.3)4.6±1.6 (12.5)4.6±1.0 (16.6)0.9534.7±0.9 (5.5)4.6±1.1 (20.0)0.801
Token Test27.2±7.6 (37.0)28.4±7.5 (26.0)20.3±3.5 (100)0.04829.8±4.1 (17.6)21.5±3.2 (100)0.004
Trail Making A168.9±153.8 (59.2)123.6±103.7 (47.6)327.5±202.9 (83.3)0.002103.5±56.5 (50.0)293±206.3 (80.0)0.003
Trail Making B339.9±167.8 (60.0)325.45±161.2 (40.0)398.0±139.7 (60.0)0.367329.4±160.4 (60.0)372.5±147.3 (50.0)0.634
NPI10.4±10.79.9±10.312.6±13.00.5848.2±8.68.4±8.60.968
FBI, A6.8±7.06.2±6.88.8±8.30.4465.4±5.85.8±4.30.886
FBI, B1.3±2.31.1±2.21.8±2.70.5220.7±1.00.8±1.30.892
FBI, AB8.0±8.57.4±7.910.6±10.90.4196.1±6.26.6±4.90.873
UPDRS-III19.9±11.522.7±10.77.2±4.40.00421.6±10.56.7±5.00.014
De Renzi imitation, left*55.9±14.1 (92.6)56.5±14.2 (95.4)53.4±15.2 (80.0)0.66359.2±11.6 (94.1)59.0±9.9 (75.0)0.963
De Renzi imitation, right*58.0±10.2 (96.3)57.0±10.6 (100)62.6±7.3 (80.0)0.28958.3±10.6 (100)63.2±8.3 (75.0)0.403
  • Percentages of patients with pathological scores, according to Italian normative data, are indicated in parentheses.

  • * De Renzi cut-off value of <62 is used.

  • AD, Alzheimer's disease; CBS, corticobasal syndrome; FBI, Frontal Behavioural Inventory; MMSE, Mini-Mental State Examination; nAD-like, non-Alzheimer's disease-like; NPI, Neuropsychiatry Inventory; SPECT, single photon emission computed tomography; UPDRS-III, Unified Parkinson's Disease Rating Scale.