Mean (SD) diffusion measures from the corticospinal tracts in patient groups and controls
| Sporadic amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis patients homozygous for aspartate-to-alanine mutations in codon 90 | Controls | Statistics | |
| Diffusion measures | ||||
| Fractional anisotropy | 0.46 (0.03)* | 0.53 (0.02) | 0.51 (0.04) | F=13.8, p<0.001 |
| Mean diffusivity (10−3 mm2/s) | 0.72 (0.04) | 0.70 (0.02) | 0.69 (0.03) | F=3.1, p=0.06 |
| Radial diffusivity (10−3 mm2/s) | 0.52 (0.04)* | 0.46 (0.02) | 0.47 (0.03) | F=10.0, p<0.001 |
| Axial diffusivity (10−2 mm2/s) | 0.11 (0.05) | 0.12 (0.04) | 0.11 (0.07) | F=1.9, p=0.16 |
↵* Sporadic amyotrophic lateral sclerosis group different from both the group of amyotrophic lateral sclerosis patients homozygous for aspartate-to-alanine mutations in codon 90 (p<0.001) and controls (p<0.001).