Clinical and MR parameters after 3 years of follow-up
| RRMS (n=60) | RRMS/E (n=32) | p Value | |
| EDSS change | 0.3±0.2 (0–2.0) | 0.7±0.5 (0–2.0) | <0.001 |
| New white matter lesion number | 1.8±1.3 (0–5) | 2.3±2.0 (0–6) | 0.071 |
| Patients with new white matter lesion (%) | 41 (68.3%) | 24 (75.0%) | 0.50 |
| Δ-T2WMLV | 0.7±0.5 (0–1.5) | 0.9±0.6 (0–1.4) | 0.127 |
| New CLs number | 1.2±1.1 (0–6) | 3.4±3.2 (0–7) | <0.001 |
| Patients with new CLs (%) | 26 (43.3%) | 27 (84.4%) | <0.001 |
| Δ-GMf | 0.5±0.3 (0.2–1.0) | 0.7±0.2 (0.5–1.4) | 0.022 |
| Δ-CS | 4.0±3.7 (0–10) | 1.3±2.0 (0–6) | 0.002 |
Data are expressed as mean (SD; range).
CLs, cortical lesions; Δ-CS, cognitive score change; Δ-GMf, annualised grey matter fraction change; Δ-T2WMLV, T2 white matter lesion volume change; EDSS, Expanded Disability Status Scale; RRMS, relapsing–remitting multiple sclerosis; RRMS/E, relapsing–remitting multiple sclerosis with epilepsy.